253862-99-6

Basic information

• Product Name: Acetamide, N-(3-chlorophenyl)-2-[[[1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl]meth yl](2-hydroxyethyl)amino]-
• CAS NO: 253862-99-6
• Molecular Formula: C22H22ClN5O2
• Molecular Weight: 423.902
• Mol File: 253862-99-6.mol

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(3-chlorophenyl)-2-[[[1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl]meth yl](2-hydroxyethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(3-chlorophenyl)-2-[[[1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl]meth yl](2-hydroxyethyl)amino]-(253862-99-6)
• EPA Substance Registry System: Acetamide, N-(3-chlorophenyl)-2-[[[1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl]meth yl](2-hydroxyethyl)amino]-(253862-99-6)

Safety Data

• Hazardous Substances Data: 253862-99-6(Hazardous Substances Data)

Upstream product

• 183500-36-9 4-(5-hydroxymethyl-imidazol-1-ylmethyl)-benzonitrile 
• 108-42-9 3-chloro-aniline 
• 2564-05-8 2-chloro-N-(3-chlorophenyl)acetamide 
• 215649-70-0 N¹-(3-chlorophenyl)-N²-(2-hydroxyethyl)glycinamide 

Downstream Products

• 183499-57-2 1-(3-chlorophenyl)-4-[1-(4-cyanobenzyl)-5-imidazolylmethyl]-2-piperazinone 

Relevant articles and documents

Preparation of a clinically investigated ras farnesyl transferase inhibitor

The synthesis of ras farnesyl-protein transferase inhibitor 1 is described on a multi-kilogram scale. Retrosynthetic analysis reveals chloromethylimidazole 2 and a piperazinone 3 as viable precursors. The 1,5-disubstituted imidazole system was regioselectively assembled via an improved Marckwald imidazole synthesis. A new imidazole dethionation procedure has been developed to convert the Marckwald mercaptoimidazole product to the desired imidazole. This methodology was found to be tolerant of a variety of functional groups providing good to excellent yields of 1,5-disubstituted imidazoles. A new Mitsunobu cyclization strategy was developed to prepare the arylpiperazinone fragment 3.