215649-70-0

Basic information

• Product Name: 2-(2-HYDROXYETHYLAMINO)-N-(3-CHLOROPHENYL)ACETAMIDE
• Synonyms: 2-(2-HYDROXYETHYLAMINO)-N-(3-CHLOROPHENYL)ACETAMIDE;AcetaMide,N-(3-chlorophenyl)-2-[(2-hydroxyethyl)aMino]-
• CAS NO: 215649-70-0
• Molecular Formula: C₁₀H₁₃ClN₂O₂
• Molecular Weight: 228.67542
• Mol File: 215649-70-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 470.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.315±0.06 g/cm3(Predicted)
• PKA: 13.54±0.70(Predicted)
• CAS DataBase Reference: 2-(2-HYDROXYETHYLAMINO)-N-(3-CHLOROPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-HYDROXYETHYLAMINO)-N-(3-CHLOROPHENYL)ACETAMIDE(215649-70-0)
• EPA Substance Registry System: 2-(2-HYDROXYETHYLAMINO)-N-(3-CHLOROPHENYL)ACETAMIDE(215649-70-0)

Safety Data

• Hazardous Substances Data: 215649-70-0(Hazardous Substances Data)

Usage

General Description

2-(2-Hydroxyethylamino)-N-(3-chlorophenyl)acetamide is a chemical compound with the molecular formula C10H13ClN2O2. It belongs to the acetamide family and consists of a chlorophenyl group, a hydroxyethylamino group, and an acetamide group. 2-(2-HYDROXYETHYLAMINO)-N-(3-CHLOROPHENYL)ACETAMIDE is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and medications. It is also known for its potential as an inhibitor of specific enzymes and proteins in biological systems. However, its exact properties, uses, and effects on health and the environment may vary depending on the specific application and formulation.

Upstream product

• 2564-05-8 2-chloro-N-(3-chlorophenyl)acetamide 
• 141-43-5 ethanolamine 
• 108-42-9 3-chloro-aniline 

Downstream Products

• 183499-57-2 1-(3-chlorophenyl)-4-[1-(4-cyanobenzyl)-5-imidazolylmethyl]-2-piperazinone 
• 253862-99-6 N¹-(3-chlorophenyl)-N²-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-N²-(2-hydroxyethyl)glycinamide 
• 183500-94-9 1-(3-chlorophenyl)-2-piperazinone hydrochloride 

Relevant articles and documents

Synthesis and cytotoxicity evaluation of some novel 1-(3-Chlorophenyl) piperazin-2-one derivatives bearing imidazole bioisosteres

A series of substituted 3-chlorophenylpiperazinone derivatives were synthesised using L-778123 (an imidazole-containing FTase inhibitor) as a model by bioisosteric replacement of the imidazole ring. The final compounds were evaluated against two human cancer cell lines including A549 (lung cancer) and HT-29 (colon cancer) by MTT assay. The results showed that substitution of imidazole ring with 1-amidinourea, semicarbazide, and thiobiuret led to improvement of cytotoxic activity against both cell lines.

Efficient synthesis of N-arylpiperazinones via a selective intramolecular Mitsunobu cyclodehydration

A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%.