253866-82-9Relevant articles and documents
A novel and simple asymmetric synthesis of CMI-977 (LDP-977): A potent anti-asthmatic drug lead
Gurjar, Mukund K.,Murugaiah,Radhakrishna,Ramana,Chorghade, Mukund S.
, p. 1363 - 1370 (2007/10/03)
A practical gram scale asymmetric synthesis of CMI-977 is described. A tandem double elimination of an α-chlorooxirane and concomitant intramolecular nucleophilic substitution was used as the key step. Jacobsen hydrolytic kinetic resolution and Sharpless
Substituted oxygen alicyclic compounds, including methods for synthesis thereof
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, (2008/06/13)
The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.
Methods for synthesis of substituted tetrahydrofuran compound
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, (2008/06/13)
The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1-butynyl)-tetrahydrofuran and precursors thereof.