104605-97-2

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-((4-FLUOROPHENOXY)METHYL)OXIRANE is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the creation of new drugs and biologically active molecules, contributing to the development of novel treatments for various medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, (R)-2-((4-FLUOROPHENOXY)METHYL)OXIRANE is used as a key component in the synthesis of agrochemicals. Its properties make it suitable for the development of new pesticides, herbicides, and other agricultural chemicals that can help improve crop yields and protect plants from pests and diseases.
Used in Material Science:
(R)-2-((4-FLUOROPHENOXY)METHYL)OXIRANE is also utilized in the field of material science. Its high reactivity and specificity make it an ideal reagent for chemical reactions, leading to the development of new materials with specific properties for various applications, such as in electronics, coatings, and adhesives.
Used as a Reagent in Chemical Reactions:
Due to its high reactivity and specificity, (R)-2-((4-FLUOROPHENOXY)METHYL)OXIRANE is often used as a reagent in chemical reactions. This allows for the synthesis of a wide range of compounds with specific properties, which can be applied in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 371-41-5 4-Fluorophenol 
• 106-89-8 epichlorohydrin 
• 18123-82-5 2-(4-fluorophenoxymethyl)oxirane 
• 453-17-8 D-Glyceraldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 51594-55-9 (R)-(-)-epichlorohydrin 
• 591235-75-5 (S)-4-[(4-fluorophenoxy)methyl]-2,2-dimethyl-1,3-dioxolane 
• 104605-95-0 (2R)-1-(4-fluorophenoxy)propane-2,3-diol 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 13990-72-2 1-allyloxy-4-fluorobenzene 

Downstream Products

• 66307-49-1 1-(2-hydroxy-3-phenylpiperazinopropoxy)-4-fluorobenzene 
• 104605-98-3 (2S)-2-[(4-fluorophenoxy)methyl]oxirane 
• 104605-95-0 (2R)-1-(4-fluorophenoxy)propane-2,3-diol 
• 220623-71-2 (2S,5S)-trans-5-((4-fluorophenoxy)methyl)-2-(1-hydroxy-3-butyn-4-yl)tetrahydrofuran 
• 175212-45-0 (2S,5S)-trans-5-(4-fluorophenoxymethyl)-5-(4-N,O-bis-(phenoxycarbonyl)hydroxylamino-3-butyn-4-yl)tetrahydrofuran 
• 253866-82-9 (2R)-1-(4-fluoro)phenoxyhex-5-en-2-ol 
• 253866-88-5 (2S,5S)-2-ethynyl-5-[(4-fluorophenoxy)methyl]tetrahydrofuran 
• 254891-87-7 Benzenesulfonic acid (R)-1-(4-fluoro-phenoxymethyl)-4-oxo-butyl ester 
• 253866-83-0 (2R)-2-benzenesulfonyloxy-1-(4-fluorophenoxy)-5-hexene 
• 253866-85-2 (2E,6R)-6-benzenesulfonyloxy-7-(4-fluorophenoxy)hept-1-en-1-ol 
• 253866-86-3 (2S,3S,6R)-6-benzenesulfonyloxy-2,3-epoxy-7-(4-fluorophenoxy)heptan-1-ol 
• 253866-87-4 (2R,3S,6R)-6-benzenesulfonyloxy-1-chloro-2,3-epoxy-7-(4-fluorophenoxy)heptane 
• 253866-84-1 ethyl (2E,6R)-6-benzenesulfonyloxy-7-(4-fluorophenoxy)hept-1-en-1-oate 

Relevant academic research and scientific papers

A new synthesis of sultams from amino alcohols

The base-mediated cyclization of N,O-dimesylate derivatives of cyclic and acyclic amino alcohols provides a simple access to five- and six-member sultams: isothiazolidine-1,1-dioxides and thiazinane-1,1-dioxides respectively.

Chemoselective Epoxidation of Allyloxybenzene by Hydrogen Peroxide Over MFI-Type Titanosilicate

The chemoselective synthesis of 2-(phenoxymethyl)oxirane from allyloxybenzene is achieved with over 90 % yield in a sustainable reaction system using titanium-substituted silicalite-1 (TS-1) as a catalyst, hydrogen peroxide (H2O2) as an oxidant, and a mixture of MeOH/MeCN as a solvent at 40 °C. No acid-catalyzed side reactions prompted by the Lewis acidity of the Ti active site in TS-1 are observed. The TS-1 catalyst can also promote the formation of oxiranes from various p-substituted allyloxybenzenes in good yields. The reaction mechanism is investigated through the reaction with other allyloxy compounds. The results, which are supported by DFT calculations, indicate that an active species of Ti peroxides formed from the reaction of TS-1 with H2O2 selectively oxidizes the allyloxybenzene to 2-(phenoxymethyl)oxirane.

Montmorillonite K10 catalyzed highly regioselective azidolysis of epoxides: A short and efficient synthesis of phenylglycine

A series of β‐hydroxyazides were effectively synthesized from the regioselective ring opening of epoxides by sodium azide using montmorillonite K10 as a novel heterogeneous catalyst in aqueous acetonitrile in good to excellent yields. The utility of this method has been demonstrated by achieving a short synthesis of phenylglycine in 33.5% overall yield.

Synthesis of 2-(phenoxymethyl)oxirane derivatives through unexpected rearrangement of oxiran-2-ylmethyl benzenesulfonates

The synthesis of 2-(phenoxymethyl)oxirane derivatives from oxiran-2-ylmethyl benzenesulfonates was developed through a base promoted rearrangement. A new C-O bond was formed along with the unexpected cleavage of C-S bond via this process. This unusual reaction was characterized with mild reaction conditions, high efficiency, and excellent functional group tolerance. A plausible reaction mechanism was proposed on the basis of experimental results and control experiments.

Solvent-Directed Epoxide Opening with Primary Amines for the Synthesis of β-Amino Alcohols

An efficient synthesis of β-amino alcohols from a variety of epoxides and primary unbranched amines in the absence of any catalyst in high yields and regioselectivities is reported. A variety of polar mixed solvent systems allow for the selective formation of secondary amino alcohols over tertiary amino alcohols. The reaction scope extends to a wide variety of aromatic and aliphatic substituted epoxides and primary amines bearing complex functionality.

ANTI-INFECTIVE COMPOUNDS

The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.

Stereoselective total synthesis of the potent anti-asthmatic compound CMI-977 (LDP-977)

A short and efficient stereoselective total synthesis of CMI-977 (LDP-977), a potent and orally active anti-asthmatic compound, was developed. The key steps involve a highly diastereoselective Mukaiyama oxidative cyclization, which provides the trans-THF (tetrahydrofuran) unit and a Seyferth-Gilbert homologation to construct the triple bond in the target molecule. The synthesis of the key chiral building block was performed using Jacobsen hydrolytic kinetic resolution.

Novel Benzyl Sulfonamide Derivatives Useful As MOGAT-2 Inhibitors

The present invention provides compounds of Formula below: and analogues thereof where the various substituent groups, R1, R2, R3, R4, R5 A, and X are described herein; or a pharmaceutical salt thereof; a method of treating a condition such as hypertrigly

Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl) piperazine derivatives as T-type calcium channel blockers

To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 2-hydroxy-3-phenoxypropyl piperazine derivatives were synthesized and evaluated for in vitro activities. Compound 6m and 6q showed high selectivity over hERG

SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.