253867-31-1

Basic information

• Product Name: (2S)-2-(hydroxymethyl)-5-[1-(4-methoxybenzyloxy)-3-butyn-4-yl]tetrahydrofuran
• Synonyms: (2S)-2-(hydroxymethyl)-5-[1-(4-methoxybenzyloxy)-3-butyn-4-yl]tetrahydrofuran
• CAS NO: 253867-31-1
• Molecular Weight: 290.359
• Mol File: 253867-31-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-2-(hydroxymethyl)-5-[1-(4-methoxybenzyloxy)-3-butyn-4-yl]tetrahydrofuran(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-(hydroxymethyl)-5-[1-(4-methoxybenzyloxy)-3-butyn-4-yl]tetrahydrofuran(253867-31-1)
• EPA Substance Registry System: (2S)-2-(hydroxymethyl)-5-[1-(4-methoxybenzyloxy)-3-butyn-4-yl]tetrahydrofuran(253867-31-1)

Safety Data

• Hazardous Substances Data: 253867-31-1(Hazardous Substances Data)

Upstream product

• 851532-55-3 (2R)-5-acetoxy-1,2-dihydroxy-9-(4-methoxybenzyloxy)non-6-yne 
• 851532-54-2 (2R)-5-acetoxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne 
• 851532-53-1 (2R)-5-hydroxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne 
• 36326-38-2 ethyl (R,Z)-3-(2′,2′-dimethyl-1′,3′-dioxolan-4′-yl)acrylate 
• 173152-84-6 ethyl (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionate 
• 851532-56-4 (2R)-5-acetoxy-2-hydroxy-9-(4-methoxybenzyloxy)-1-(p-toluenesulfonyloxy)non-6-yne 
• 133008-08-9 (4R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-ol 
• 133008-09-0 (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propanal 

Downstream Products

• 254891-83-3 (5S)-5-((4-fluorophenoxy)methyl)-2-[1-(4-methoxybenzyloxy)-3-butyn-4-yl]tetrahydrofuran 
• 220623-71-2 (2S,5S)-trans-5-((4-fluorophenoxy)methyl)-2-(1-hydroxy-3-butyn-4-yl)tetrahydrofuran 
• 254891-82-2 (2S)-5-[1-(4-methoxybenzyloxy)-3-butyn-4-yl]-2-(p-toluenesulfonyloxy)tetrahydrofuran 

Relevant articles and documents

Stereoselective synthesis of chiral tetrahydrofurans with potent 5-LO inhibitory activity

Chiral glyceraldehydes have been exploited for the design of convenient and scalable synthetic approaches to chiral tetrahydrofurans, which have potential as potent 5-lipoxygenase (5-LO) inhibitors. The synthesis of all four possible stereoisomers by a general methodology is reported; wherein the chirons derived from the glyceraldehyde derivatives on reaction with homopropargyl ether, cyclization and further reactions gave the targets.