25388-00-5

Basic information

• Product Name: 2-Oxazolidinone, 3-benzoyl-5-(chloromethyl)-
• CAS NO: 25388-00-5
• Molecular Formula: C11H10ClNO3
• Molecular Weight: 239.658
• Mol File: 25388-00-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 3-benzoyl-5-(chloromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 3-benzoyl-5-(chloromethyl)-(25388-00-5)
• EPA Substance Registry System: 2-Oxazolidinone, 3-benzoyl-5-(chloromethyl)-(25388-00-5)

Safety Data

• Hazardous Substances Data: 25388-00-5(Hazardous Substances Data)

Upstream product

• 22625-57-6 5-(chloromethyl)-1,3-oxazolidin-2-one 
• 98-88-4 benzoyl chloride 
• 106-89-8 epichlorohydrin 
• 4461-33-0 benzoyl isocyanate 

Relevant articles and documents

Tetraarylphosphonium Salt-Catalyzed Synthesis of Oxazolidinones from Isocyanates and Epoxides

Preparation of a range of oxazolidinones, including enantioenriched N-aryl-substituted oxazolidinones, in which tetraarylphosphonium salts (TAPS) catalyze the [3 + 2] coupling reaction of isocyanates and epoxides effectively, is described. The key finding is a Br?nsted acid/halide ion bifunctional catalyst that can accelerate epoxide ring opening with high regioselectivity. Mechanistic studies disclosed that the ylide generated from TAPS, along with the formation of halohydrins, plays a crucial role in the reaction with isocyanates.