929074-45-3

Usage

Uses

Used in Pharmaceutical Industry:
8-Bromo-pyrido[3,4-b]pyrazine is used as a key intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs with enhanced therapeutic properties. Its unique structure allows for the creation of diverse molecular entities that can target specific biological pathways or receptors, thereby addressing unmet medical needs.
Used in Agrochemical Industry:
In the agrochemical sector, 8-Bromo-pyrido[3,4-b]pyrazine is utilized as a starting material for the production of pesticides and other crop protection agents. Its incorporation into these compounds can lead to improved efficacy against pests and diseases, as well as reduced environmental impact compared to traditional agrochemicals.
Used in Organic Synthesis:
8-Bromo-pyrido[3,4-b]pyrazine is employed as a reagent in organic synthesis, where it can participate in a variety of chemical reactions. These reactions enable the formation of more complex and functionalized molecules, which can be further utilized in the development of specialty chemicals, materials, or other advanced organic compounds.
Used in Medicinal Chemistry Research:
As a versatile chemical entity, 8-Bromo-pyrido[3,4-b]pyrazine is used in medicinal chemistry research to explore its potential as a precursor for the synthesis of novel bioactive molecules. Researchers leverage its unique structural features to design and synthesize new compounds with potential applications in drug discovery and development, aiming to identify lead candidates for the treatment of various diseases and conditions.

InChI:InChI=1/C7H4BrN3/c8-5-3-9-4-6-7(5)11-2-1-10-6/h1-4H

Upstream product

• 54-96-6 3,4-diaminopyridine 
• 254-86-4 pyrido[3,4-b]pyrazine 
• 4635-08-9 3,4-diamino-5-bromopyridine 
• 131543-46-9 Glyoxal 

Relevant academic research and scientific papers

Annelated Pyridine Bases for the Selective Acylation of 1,2-Diols

A set of 24 annelated derivatives of 4-diaminopyridine (DMAP) has been synthesized and tested with respect to its catalytic potential in the regioselective acylation of 1,2-diol substrates. The Lewis basicities of the catalysts as quantified through quantum chemical calculations vary due to inductive substituent effects and intramolecular stacking interactions between side chain π-systems and the pyridinium core ring system. The primary over secondary hydroxyl group selectivities in catalytic acylations of 1,2-diol substrates depend on the size and the steric demand of the Lewis base and the anhydride reagent.

2,3-DISUBSTITUTED PYRIDO[3,4-B]PYRAZINE-CONTAINING COMPOUNDS AS KINASE INHIBITORS

The present invention generally relates to 2,3-Disubstituted pyrido[3,4- b]pyrazine-containing compounds as a kinase inhibitor and methods of uses thereof. Pharmaceutical compositions and methods for treating those kinase related diseases are within the scope of this invention.

BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME

Provided is a compound showing excellent antifungal activity against Trichophyton fungus, which is a major causative microorganism of superficial mycosis, and high effectiveness on diseases caused by Trichophyton fungi. A biaryl derivative represented by the formula (I) or a salt thereof: wherein ring A is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered ring heteroaryl (ring A may be further condensed to form an optionally substituted fused ring); Q is CH2, C=O, NH, O, S or the like; X1, X2 and X3 are CR1 or N; Y is CH or N; Z is CR2b or N; R2a and R2b are each a hydrogen atom, a halogen atom, an optionally substituted C1-C6 alkyl group, a C1-C6 haloalkyl group or the like; R2a and R2b may form, together with carbon atoms bonded thereto, an optionally substituted carbocycle, or an optionally substituted heterocycle.

PHARMACEUTICALS COMPRISING BIARYL DERIVATIVES OR SALTS THEREOF

PROBLEM TO BE SOLVED: To provide compounds with excellent antimycotic activity against Trichophyton. SOLUTION: The invention provides pharmaceuticals comprising biaryl derivatives represented by general formula (I) or salts thereof, where ring A is optionally substituted phenyl or the like; Q is CH2 or the like; X1, X2 and X3 are CR1 or the like; and Y is CH or N. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Annelated pyridines as highly nucleophilic and Lewis basic catalysts for acylation reactions

New heterocyclic derivatives of 9-azajulolidine have been synthesized and characterized with respect to their nucleophilicity and Lewis basicity. The Lewis basicity of these bases as quantified through their theoretically calculated methyl-cation affinities correlate well with the experimentally measured reaction rates for addition to benzhydryl cations. All newly synthesized pyridines show exceptional catalytic activities in benchmark acylation reactions, which correlate only poorly with Lewis basicity or nucleophilicity parameters. A combination of Lewis basicity with charge and geometric parameters in the framework of a three-component quantitative structure-activity relationship (QSAR) model is, however, highly predictive. Copyright