41679-97-4Relevant academic research and scientific papers
Iodine-catalyzed etherification of morroniside
Sunghwa, Fortunatus,Sakurai, Hiroaki,Saiki, Ikuo,Koketsu, Mamoru
, p. 112 - 115 (2009)
In this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours under neutr
Morroniside cinnamic acid conjugate as an anti-inflammatory agent
Takeda, Yoshinori,Tanigawa, Naomi,Sunghwa, Fortunatus,Ninomiya, Masayuki,Hagiwara, Makoto,Matsushita, Kenji,Koketsu, Mamoru
, p. 4855 - 4857 (2010)
A morroniside cinnamic acid conjugate was prepared and evaluated on E-selectin mediated cell-cell adhesion as an important role in inflammatory processes. 7-O-Cinnamoylmorroniside exhibited excellent anti-inflammatory activity (IC50 = 49.3 μM) by inhibiting the expression of E-selectin; further, it was more active than another cinnamic-acid-conjugated iridoid glycoside (harpagoside; IC50 = 88.2 μM), 7-O-methylmorroniside, and morroniside itself. As a result, 7-O- cinnamoylmorroniside was observed to be a potent inhibitor of TNF-α-induced E-selectin expression.
