254112-79-3Relevant academic research and scientific papers
Development of a New Family of Conformationally Restricted Peptides as Potent Nucleators of β-Turns. Design, Synthesis, Structure, and Biological Evaluation of β-Lactam Peptide Analogue of Melanostatin
Palomo, Claudio,Aizpurua, Jesus M.,Benito, Ana,Miranda, Jose Ignacio,Fratila, Raluca M.,Matute, Carlos,Domercq, Maria,Gago, Federico,Martin-Santamaria, Sonsoles,Linden, Anthony
, p. 16243 - 16260 (2007/10/03)
Novel enantiopure (i)-(β-lactam)-(Gly)-(i+3) peptide models, defined by the presence of a central α-alkyl-αamino-β-lactam ring placed as the (i+1) residue, have been synthesized in a totally stereocontrolled way by α-alkylation of suitable N-[bis(trimethy
On the question of the diastereoselective alkylation of 4-unsubstituted 3-amino β-lactams. A concise synthesis of α-branched α-amino β-lactams and their coupling with α-amino acid esters
Palomo, Claudio,Aizpurua, Jesus M.,Galarza, Regina,Benito, Ana,Khamrai, Uttam K.,Eikeseth, Unni,Linden, Anthony
, p. 5563 - 5570 (2007/10/03)
The reaction of [(4S)-2-oxo-4-phenyloxazolidin-3-yl]acetic acid chloride with N-methylidene-bis-[(trimethylsilyl)methyl]amine and triethylamine in refluxing chloroform leads to a 4-unsubstituted β-lactam able to undergo highly asymmetric alkylations at th
α-alkyl-α-amino-β-lactam peptides: Design, synthesis, and conformational features
Palomo, Claudio,Aizpurua, Jesus M.,Benito, Ana,Galarza, Regina,Khamrai, Uttam K.,Vazquez, Jordi,De Pascual-Teresa, Beatriz,Nieto, Pedro M.,Linden, Anthony
, p. 3056 - 3058 (2007/10/03)
Remarkable asymmetric induction is achieved in the alkylation of the lithium enolate of the β-lactam 1. This allows the first time access to a new family of peptidomimetics 2 with predictable conformational constraints.
