187161-86-0

Upstream product

• 99333-55-8 2-(4(S)-phenyloxazolidin-2-on-3-yl)acetyl chloride 
• 153725-08-7 N-Methylideneamine 
• 198022-09-2 (S)-3-[(3S,4R)-1-(Bis-trimethylsilanyl-methyl)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-4-phenyl-oxazolidin-2-one 
• 198021-49-7 (2S,3S)-1-(Bis-trimethylsilanyl-methyl)-4-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-azetidine-2-carboxylic acid 
• 123017-04-9 (Bis-trimethylsilanyl-methyl)-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-amine 
• 134340-00-4 bis(trimethylsilyl)methylamine 

Downstream Products

• 254112-79-3 (3R)-1-[bis(trimethylsilyl)methyl]-3-(3-methylpropyl)-3-[(4S)-2-oxo-4-phenyloxazolidin-3-yl]azetidin-2-one 
• 254112-83-9 (3R)-3-benzyl-1-bis(trimethylsilyl)methyl-3-[(4S)-2-oxo-4-phenyloxazolidin-3-yl]azetidin-2-one 
• 254112-80-6 (3R)-1-[bis(trimethylsilyl)methyl]-3-[(2-methylphenyl)methyl]-3-[(4S)-2-oxo-4-phenyloxazolidin-3-yl]azetidin-2-one 
• 656826-64-1 (3R)-1-[bis(trimethylsilyl)methyl]-3-(2-methyl-2-propenyl)-3-[(4S)-4-phenyl-2-oxo-1,3-oxazolidin-3-yl]azetidin-2-one 
• 301161-15-9 (3R)-3-benzyl-1-bis(trimethylsilyl)methyl-3-(tert-butoxycarbonylamino)azetidin-2-one 
• 651749-92-7 (3R)-1-[(aminocarbonyl)methyl]-3-isobutyl-3-[(4S)-4-phenyl-2-oxo-1,3-oxazolidin-3-yl]azetidin-2-one 

Relevant academic research and scientific papers

N-Methylidene[bis(trimethylsilyl)methyl]amine: The first isolable and stable monomeric methanimine allowing thermal [2 + 2] cycloadditions with ketenes

N-Methylidene[bis(trimethylsilyl)methyl]amine acts as a stable methanimine synthon [CH2=NH] equivalent in [2 + 2] cycloadditions to ketenes, generated from acid chlorides and triethylamine, to provide 4-unsubstituted β-lactams in a single step.

A contribution to the asymmetric synthesis of 3-amine β-lactams: The diastereoselective [2+2] cycloaddition reaction of chiral aminoketene equivalents with enolizable aldehyde-derived/mines

N-[Bis(trimethylsilyl)methyl]imines 9 show unique chemical properties when compared with conventional imines. Their reaction with optically pure aminoketenes derived from dehydrochlorination of 14 and 15 affords the corresponding 3-amino-4-alkyl-β-lactams