651749-92-7

Basic information

• Product Name: (3R)-1-[(aminocarbonyl)methyl]-3-isobutyl-3-[(4S)-4-phenyl-2-oxo-1,3-oxazolidin-3-yl]azetidin-2-one
• Synonyms: (3R)-1-[(aminocarbonyl)methyl]-3-isobutyl-3-[(4S)-4-phenyl-2-oxo-1,3-oxazolidin-3-yl]azetidin-2-one
• CAS NO: 651749-92-7
• Molecular Weight: 345.398
• Mol File: 651749-92-7.mol

Chemical Properties

• CAS DataBase Reference: (3R)-1-[(aminocarbonyl)methyl]-3-isobutyl-3-[(4S)-4-phenyl-2-oxo-1,3-oxazolidin-3-yl]azetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-1-[(aminocarbonyl)methyl]-3-isobutyl-3-[(4S)-4-phenyl-2-oxo-1,3-oxazolidin-3-yl]azetidin-2-one(651749-92-7)
• EPA Substance Registry System: (3R)-1-[(aminocarbonyl)methyl]-3-isobutyl-3-[(4S)-4-phenyl-2-oxo-1,3-oxazolidin-3-yl]azetidin-2-one(651749-92-7)

Safety Data

• Hazardous Substances Data: 651749-92-7(Hazardous Substances Data)

Upstream product

• 656826-64-1 (3R)-1-[bis(trimethylsilyl)methyl]-3-(2-methyl-2-propenyl)-3-[(4S)-4-phenyl-2-oxo-1,3-oxazolidin-3-yl]azetidin-2-one 
• 187161-86-0 (3S)-1-[bis(trimethylsilyl)methyl]-3-[(4S)-4-phenyl-2-oxo-1,3-oxazolidin-3-yl]azetidin-2-one 
• 1118-02-1 trimethylsilyl isocyanate 
• 254112-79-3 (3R)-1-[bis(trimethylsilyl)methyl]-3-(3-methylpropyl)-3-[(4S)-2-oxo-4-phenyloxazolidin-3-yl]azetidin-2-one 

Downstream Products

• 651749-59-6 (3R)-1-amidomethyl-3-isobutyl-3-[(2S)-pyrrolidin-2-ylcarbonylamino]azetidin-2-one 

Relevant articles and documents

Functionalization of N-[(silyl)methyl]-β-lactam carbanions with carbon electrophiles

Latent acidity of α-alkyl-α-amino-N-[(silyl)methyl]-β- lactams enabled a concise entry to lithium nonenolate N-methyl-azetidinone carbanions lithiated α′ to the β-lactam nitrogen, owing to the stabilizing "α-effect" of one or two trimethylsilyl groups. s

Development of a New Family of Conformationally Restricted Peptides as Potent Nucleators of β-Turns. Design, Synthesis, Structure, and Biological Evaluation of β-Lactam Peptide Analogue of Melanostatin

Novel enantiopure (i)-(β-lactam)-(Gly)-(i+3) peptide models, defined by the presence of a central α-alkyl-αamino-β-lactam ring placed as the (i+1) residue, have been synthesized in a totally stereocontrolled way by α-alkylation of suitable N-[bis(trimethy