254441-32-2

Upstream product

• 824-91-9 O-methoxymethylphenol 
• 543-24-8 N-acetylglycine 
• 254441-31-1 2-(di-o-tolylphosphino)phenol 
• 36042-94-1 bis(o-tolyl)chlorophosphine 

Downstream Products

• 254909-41-6 RhCl(P(CH₃)3)((CH₃C₆H₄)2PC₆H₄O)(COCH₂NHCOCH₃) 
• 757961-29-8 RhCl(P(CH₃)2C₆H₅)(OC₆H₄P(C₆H₄CH₃)2)(COCH₂NHCOCH₃) 
• 757961-31-2 Rh⁽³⁺⁾*NH₂N(CH₃)2*OC₆H₄P(C₆H₄CH₃)2^(1-)*COCH₂NHCOCH₃^(1-)*Cl^(1-)=RhCl(NH₂N(CH₃)2)(OC₆H₄P(C₆H₄CH₃)2)(COCH₂NHCOCH₃) 
• 757961-22-1 RhCl((CH₃C₆H₄)2PC₆H₄O)(COCH₂NHCOCH₃) 

Relevant academic research and scientific papers

Controlled oxidative addition of amino acid esters to Rh(I)

The new sterically demanding phosphine 2-(di-o-tolylphosphino)phenol was prepared and used to create a series of esters with N-acylated amino acids. The phosphine-containing esters react within 30-60 min at room temperature with [(μ-Cl)Rh(cyclooctene)2]2 to give products of oxidative addition of the ester carbonyl-oxygen bond to the Rh center. The N-acyl carbonyl oxygen is bound to the Rh in these initial adducts, but is displaced upon addition of PMe3. Remarkably, both initial products and their PMe3 adducts are formed as single five-coordinate diastereomers in essentially quantitative yields.