25467-53-2Relevant articles and documents
A convenient 'catch and release' synthesis of fused 2-alkylthio-pyrimidinones mediated by polymer-bound BEMP
Adams, Gregory L.,Graybill, Todd L.,Sanchez, Robert M.,Magaard, Victoria W.,Burton, George,Rivero, Ralph A.
, p. 5041 - 5045 (2007/10/03)
A robust 'catch and release' synthesis of fused 2-alkylthio-3-substituted-pyrimidinones mediated by the polymer-bound base P-BEMP is described. This reengineered synthesis combines the efficiency of the classical synthesis (three steps, three diversity points) with the practical benefits of resin-bound reagents. The solution-phase strategy, reagent compatibility, and the results of a representative 48-member combinatorial library are described and presented herein.