4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-formylbromobenzene

Base Information

• Chemical Name: 4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-formylbromobenzene
• CAS No.: 254744-56-4
• Molecular Formula: C₁₉H₂₃BrN₂O₂
• Molecular Weight: 391.308
• Mol file: 254744-56-4.mol

Synonyms:4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-formylbromobenzene

Chemical Property of 4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-formylbromobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-formylbromobenzene

There total 7 articles about 4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-formylbromobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene (254744-55-3) → 4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-formylbromobenzene (254744-56-4)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 65 ℃; for 1h;

DOI:10.1021/jm020138n

Reference yield:

2-[(2'-bromo-5'-hydroxymethyl)phenyl]-1,3-dioxolane (160313-48-4) → 4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-formylbromobenzene (254744-56-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 31.1 g / carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 2 h / 0 °C

2.1: sodium hydride / dimethylformamide / 0.25 h / 0 - 20 °C

2.2: 42.7 g / dimethylformamide / 14 h

3.1: 8.2 g / 1 N HCl / tetrahydrofuran / 1 h / 65 °C

With hydrogenchloride; carbon tetrabromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm020138n

Reference yield:

2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one (138402-05-8) → 4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-formylbromobenzene (254744-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / dimethylformamide / 0.25 h / 0 - 20 °C

1.2: 42.7 g / dimethylformamide / 14 h

2.1: 8.2 g / 1 N HCl / tetrahydrofuran / 1 h / 65 °C

With hydrogenchloride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm020138n

upstream raw materials:

2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene

2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one

2-[(2'-bromo-5'-cyano)phenyl]-1,3-dioxolane

2-[(2'-bromo-5'-hydroxymethyl)phenyl]-1,3-dioxolane

Downstream raw materials:

4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-N-([(2-methoxy)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid

4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide