254882-54-7Relevant articles and documents
Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa
Renau, Thomas E.,Leger, Roger,Filonova, Lubov,Flamme, Eric M.,Wang, Michael,Yen, Rose,Madsen, Deidre,Griffith, David,Chamberland, Suzanne,Dudley, Michael N.,Lee, Ving J.,Lomovskaya, Olga,Watkins, William J.,Ohta, Toshiharu,Nakayama, Kiyoshi,Ishida, Yohei
, p. 2755 - 2758 (2007/10/03)
Conformational restriction of the ornithine residue of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595, 2) furnished bioisosteric proline derivatives that were less toxic in vivo and as active as the lead in potentiat
Efflux pump inhibitors
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, (2008/06/13)
Compounds are described which have efflux pump inhibitor activity. Also described are methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.