25491-56-9Relevant articles and documents
'Reductive Heck reaction' of 6-halopurines
Tobrman, Tomá?,Dvo?ák, Dalimil
, p. 273 - 276 (2004)
Alkenylation of 9-benzyl-6-halopurines with alkenes does not proceed under conventional Heck conditions. However, in the presence of triethylammonium formate a mixture of the corresponding saturated products was obtained. In contrast to the classical Heck reaction, the regioselectivity of this process is low giving a mixture of both α- and β-products regardless of the electronic nature of the substituent on the double bond of the alkene.
The synthesis of nebularine and its analogs via oxidative desulfuration in aqueous nitric acid
Xia, Ran,Sun, Li-Ping,Qu, Gui-Rong
, p. 88 - 91 (2016/12/24)
The synthesis of nebularine and its analogs has been achieved via oxidative desulfuration in H2O for the first time. With 50% HNO3as an oxidant and solvent, 18 products were obtained in good yields (70%–94%). The oxidative desulfuration system could tolerate different functional groups including fluoro, chloro, amino, alkyl, allyl, ribosyl, deoxyribosyl, and arabinofuranosyl groups.More importantly, the drug nebularine could be obtained successfully on a 20 g scale, which made this route more attractive for industrial applications.
A method for the reductive scission of heterocyclic thioethers
Graham, Thomas H.,Liu, Wensheng,Shen, Dong-Ming
supporting information; experimental part, p. 6232 - 6235 (2012/01/03)
A mild, chemoselective, and generally high-yielding method for the reductive scission of heterocyclic thioethers is described. Suitable heterocycles have a thioether substituent at the 2-position relative to a ring heteroatom. The convenient and straightforward method is demonstrated with reactants which are not compatible with the standard Raney nickel conditions such as sulfides, sulfones, and thiophenes. In addition, benzyl esters, benzyl amides, and benzyl carbamates are tolerated by the reductive reaction conditions.
