255041-82-8

Upstream product

• 76-83-5 trityl chloride 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 87184-80-3 5-tert-butyldimethylsilyloxypentanal 
• 126274-79-1 2,2-dimethyl-3-(trityloxy)propanol 

Downstream Products

• 1338704-05-4 C₂₁H₃₂O₅ 
• 1338703-90-4 C₂₁H₃₂O₅ 
• 1338704-08-7 C₂₇H₄₆O₅Si 
• 1338704-11-2 C₅₀H₈₆O₁₂Si₃ 
• 1338704-35-0 C₅₀H₈₈O₁₂Si₃ 
• 1338704-15-6 C₄₃H₇₀O₁₀Si₂ 
• 1338704-36-1 C₅₅H₉₈O₁₀Si₄ 
• 1638136-75-0 N-(3-bromoallyl)-N`-(2,2-dimethyl-3-(trityloxy)propylidene)-4-methylbenzenesulfonohydrazide 
• 1638136-77-2 (E)-N-((E)-3-bromo-2-methylbut-2-en-1-yl)-N`-(2,2-dimethyl-3-(trityloxy)propylidene)-4-methylbenzenesulfonohydrazide 
• 1638136-89-6 (E)-(((2,2-dimethylhexa-3,5-dien-1-yl)oxy)methanetriyl)tribenzene 
• 1638136-90-9 (E)-(((2,2,5-trimethylhexa-3,5-dien-1-yl)oxy)methanetriyl)tribenzene 
• 169899-61-0 1-(t-butyldiphenylsiloxy)-2-(1,3-dithian-2-yl)-2-methylpropane 

Relevant academic research and scientific papers

Single-electron/pericyclic cascade for the synthesis of dienes

The highly efficient and diastereoselective synthesis of E dienes has been accomplished through radical cyclization of bromoallyl hydrazones. This methodology has been further extended to generate these products through a one-pot condensation/radical cyclization/cycloreversion cascade from simple aldehyde starting materials in high yields (>75 %) and high diastereoselectivities (>95:5). Mechanistic investigations suggest that the cascade reaction proceeds through a cyclic diazene intermediate prior to the cycloreversion.

Stereoselective synthesis of 2,6-trans-tetrahydropyran via primary diamine-catalyzed oxa-conjugate addition reaction of α,β-unsaturated ketone: Total synthesis of psymberin

The total synthesis of psymberin was achieved employing a readily available chiral epoxide to prepare two of the three subunits in the natural product. The key reaction was a highly stereoselective organocatalytic oxa-conjugate addition reaction of α,β-un

Room-temperature metallation of 2-substituted 1,3-dithiane derivatives and subsequent coupling with 2,3-disubstituted oxiranes

2-Substituted 1,3-dithiane derivatives, (S)-1(t-butyldiphenylsiloxy)-2- (1,3-dithian-2-yl)propane (9), (S)-1-(t-butyldimethylsiloxy)-2-(1,3-dithian- 2-yl)propane, 1-(t-butyldiphenylsiloxy)-2-(1,3-dithian-2-yl)-2-methylpropane, and 1,2-bis-(t-butyldiphenylsiloxy)-3-(1,3-dithian-2-yl)propane, were subjected to lithiation in THF with n-BuLi at room temperature (r.t.); the resulting anions reacted with 2,3-disubstituted oxirane, trans-2-methyl-3- (triphenylmethoxymethyl)oxirane(22), at r.t., giving the coupling products in satisfactory yield. On the other hand, the lithium salt formed in ether from (S)2-(1,3-dithian-2-yl)-1-(4-methoxybenzyloxy)propane with n-BuLi at r.t. reacted with 22 at r.t. in the presence of hexamethylphosphoric triamide to afford the coupling product in moderate yield. In addition, a mixed organometallic reagent, n-BuLi/Bu2Mg, was found to be an effective metallation reagent for 9 and the resulting anion reacted with 22 to afford the coupling product in good yield.

Generation of 2-substituted-2-metallo-1,3-dithianes and their coupling with 1,2-disubstituted epoxides at room temperature

2-Substituted-1,3-dithianes were subjected to lithiation by n-BuLi at room temperature and the resulting anions reacted with 1,2-disubstituted epoxides at room temperature, giving the coupling products in satisfactory yield. In addition, a mixed organomet