25514-67-4

Basic information

• Product Name: 5-CYANOGRAMINE
• Synonyms: 5-CYANOGRAMINE;3-(DIMETHYLAMINOMETHYL)-5-CYANOINDOLE;RARECHEM AH BS 0092;3-((dimethylamino)methyl)-1h-indole-5-carbonitril;3-(dimethylaminomethyl)-indole-5-carbonitril;3-(dimethylaminomethyl)indole-5-carbonitrile;3-[(Dimethylamino)methyl]-1H-indole-5-carbonitrile
• CAS NO: 25514-67-4
• Molecular Formula: C12H13N3
• Molecular Weight: 199.25
• Mol File: 25514-67-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 368.2°Cat760mmHg
• Flash Point: 176.5°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 1.3E-05mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 5-CYANOGRAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CYANOGRAMINE(25514-67-4)
• EPA Substance Registry System: 5-CYANOGRAMINE(25514-67-4)

Safety Data

• Hazardous Substances Data: 25514-67-4(Hazardous Substances Data)

Usage

Uses

5-Cyanogramine is a substituted N, N-dimethyltryptamines with useful biological properties. A pharmaceutical excipient.

InChI:InChI=1/C12H13N3/c1-15(2)8-10-7-14-12-4-3-9(6-13)5-11(10)12/h3-5,7,14H,8H2,1-2H3

Upstream product

• 30354-18-8 N,N-dimethyl(methylene)ammonium chloride 
• 261177-22-4 1-Diethoxymethylindole-5-carbonitrile 
• 15861-24-2 1H-indole-5-carbonitrile 
• 497-19-8 sodium carbonate 
• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 

Downstream Products

• 17380-18-6 3-formyl-1H-indole-5-carbonitrile 

Relevant articles and documents

Rhodium-Catalyzed Enantioselective Cyclization of 3-Allenyl-indoles: Access to Functionalized Tetrahydrocarbazoles

A highly selective rhodium-catalyzed cyclization of tethered 3-allenylindoles is reported. In a smooth reaction, 1-vinyltetrahydrocarbazoles are obtained in excellent yields and enantioselectivities. Aside from a great functional group tolerance, this method requires neither the Schlenk technique nor the use of anhydrous solvents. Preliminary mechanistic investigations proved that the reaction proceeds via an intermediary formed spiroindolenine which rapidly undergoes an acid-catalyzed stereospecific migration.

INDOLYLALKYL DERIVATIVES OF PYRIMIDINYLPIPERAZINE AND METABOLITES THEREOF FOR TREATMENT OF ANXIETY, DEPRESSION, AND SEXUAL DYSFUNCTION

The present invention relates to a method for alleviation, prevention, and treatment of anxiety, depression, and sexual dysfunction by administering certain indolylalkyl derivatives of pyrimidinylpiperazine or metabolites thereof. A preferred embodiment is of the following formula:

Traceless linking of indoles: General methodology and application to solid phase supported Mannich and Stille reactions

Transacetalization reaction of the diethoxymethyl (DEM) protected indoles 2a,b,d,e with the polymer bound glycerol derivative 3 resulted in formation of the immobilized indoles 4a,b,d,e. Selective indole- functionalizations as well as quantitative and traceless cleavage could be demonstrated.