5-CYANOGRAMINE

Base Information

• Chemical Name: 5-CYANOGRAMINE
• CAS No.: 25514-67-4
• Molecular Formula: C₁₂H₁₃N₃
• Molecular Weight: 199.255
• Hs Code.: 2933990090
• Mol file: 25514-67-4.mol

Synonyms:Indole-5-carbonitrile,3-[(dimethylamino)methyl]- (8CI); 5-Cyanogramine

Chemical Property of 5-CYANOGRAMINE

Chemical Property:

• Vapor Pressure: 1.3E-05mmHg at 25°C
• Boiling Point: 368.2°Cat760mmHg
• Flash Point: 176.5°C
• PSA: 42.82000
• Density: 1.17g/cm³
• LogP: 2.10118

Purity/Quality:

97% ^*data from raw suppliers

5-Cyanogramine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Cyanogramine is a substituted N, N-dimethyltryptamines with useful biological properties. A pharmaceutical excipient.

Technology Process of 5-CYANOGRAMINE

There total 4 articles about 5-CYANOGRAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1H-indole-5-carbonitrile (15861-24-2,142396-06-3) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + dimethyl amine (124-40-3) → 3-Dimethylaminomethylindole-5-carbonitrile (25514-67-4)

Guidance literature:

With acetic acid; In 1,4-dioxane; at 20 ℃;

Reference yield:

1H-indole-5-carbonitrile (15861-24-2,142396-06-3) + aqueous dimethylamine + sodium carbonate (497-19-8) → 3-Dimethylaminomethylindole-5-carbonitrile (25514-67-4)

Guidance literature:

With formaldehyd; In ethanol; chloroform;

Reference yield:

N,N-dimethyl(methylene)ammonium chloride (30354-18-8) + 1-Diethoxymethylindole-5-carbonitrile (261177-22-4) → 3-Dimethylaminomethylindole-5-carbonitrile (25514-67-4)

Guidance literature:

1-Diethoxymethylindole-5-carbonitrile; With Merrifield resin bound glycerol; toluene-4-sulfonic acid; In 1,4-dioxane; at 20 ℃; for 3h;

N,N-dimethyl(methylene)ammonium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

With hydrogenchloride; water; In 1,4-dioxane; at 40 ℃; for 3h;

upstream raw materials:

N,N-dimethyl(methylene)ammonium chloride

1-Diethoxymethylindole-5-carbonitrile

1H-indole-5-carbonitrile

sodium carbonate

Downstream raw materials:

3-formyl-1H-indole-5-carbonitrile