255374-81-3

Usage

Molecular weight

526.72 g/mol

Structural components

piperazinecarboxylic acid, sulfonamide group, cyanophenyl group, ethyl ester group

Stereochemistry

(2S) configuration at the 3rd carbon of the propyl side chain

Potential applications

medicinal or pharmaceutical uses, synthesis of new drugs, reference compound in chemical analysis

Value in research

specific stereochemistry and arrangement of functional groups may make it valuable for drug discovery and development.

Upstream product

• 28188-41-2 m-(bromomethyl)benzonitrile 
• 367272-51-3 N-acetyl-3-cyano-(D/L)-phenylalanine 
• 57213-48-6 3-cyano-(D,L)-phenylalanine 
• 6553-96-4 2,4,6-triisopropylphenylsulfonyl chloride 
• 120-43-4 4-ethoxycarbonylpiperazine 
• 255374-80-2 Nα-2,4,6-Triisopropylphenylsulfonyl-(L)-3-cyano-phenylalanine 

Downstream Products

• 220355-63-5 WX-UK₁ 
• 255374-82-4 4-[(S)-3-(3-Thiocarbamoyl-phenyl)-2-(2,4,6-triisopropyl-benzenesulfonylamino)-propionyl]-piperazine-1-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

HYDROXYAMIDINE AND HYDROXYGUANIDINE COMPOUNDS AS UROKINASE INHIBITORS

The invention relates to novel compounds for the inhibition of the urokinase plasminogen activator (uPA) with high bioavailability and which can also be administered orally, and to the use thereof as therapeutic active ingredients for the treatment of urokinase or/and urokinase receptor associated diseases, such as, for example, tumours and metastization. The invention especially relates to compounds (I) and (II) that contain hydroxyamidine or hydroxyguanidine groups, wherein E represents a group consisting of (a).

3-Amidinophenylalanine-based inhibitors of urokinase

Synthesis and anti-uPA activity of a series of Nα-triisopropyl-phenylsulfonyl-protected 3-amidino-phenylalanine amides are described. We have explored SAR around the C-terminal amide part for inhibition of uPA, plasmin and trypsin. Modification of the ami