25560-93-4

Upstream product

• 108-05-4 vinyl acetate 
• 81867-37-0 benzyl iodoacetate 
• 100-51-6 benzyl alcohol 
• 108-24-7 acetic anhydride 
• 91970-62-6 benzyl 4-hydroxybutanoate 
• 127-08-2 potassium acetate 
• 126430-46-4 benzyl 4-bromobutanoate 

Downstream Products

• 26976-72-7 4-acetoxybutyric acid 

Relevant academic research and scientific papers

A Giese reaction for electron-rich alkenes

A general method for the hydroalkylation of electron-rich terminal and non-terminal alkenes such as enol esters, alkenyl sulfides, enol ethers, silyl enol ethers, enamides and enecarbamates has been developed. The reactions are carried out at room temperature under air initiation in the presence of triethylborane acting as a chain transfer reagent and 4-tert-butylcatechol (TBC) as a source of hydrogen atom. The efficacy of the reaction is best explained by very favorable polar effects supporting the chain process and minimizing undesired polar reactions. The stereoselective hydroalkylation of chiralN-(alk-1-en-1-yl)oxazolidin-2-ones takes place with good to excellent diastereocontrol.

PANTETHEINE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I), (II), or (II'): (I), (II), (II'), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.

NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF

The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.

ENHANCED TISSUE PENETRATION PRODRUGS

The present invention relates to derivatives of carboxy-containing drugs for enhancing tissue penetration and pharmaceutical compositions comprising such derivatives.

Acyl guanidine and amidine prodrugs

Acyl guanidine, thioguanidine and amidine compounds are provided which have the structure*(formula 06)* wherein Z is a substructure which when linked to*(formula 07)* forms a prodrug of compounds with pharmaceutically active properties. In preferred embodiments, Z is a thrombin inhibitor substructure containing residues binding at the distal and proximal sites with the proviso that Z does not contain boron or a boron-containing moiety. Ax and A'x may be the same or different and are independently selected from Acyl, H or alkyl, at least one of Ax and A'x being Acyl; and including all stereoisomers thereof, and pharmaceutically acceptable salts thereof.