25589-41-7

Basic information

• Product Name: 4-[(4-bromophenyl)amino]-4-oxobutanoic acid
• Synonyms: 4-[(4-bromophenyl)amino]-4-oxobutanoic acid;Albb-006582;4'-BROMOSUCCINANILIC ACID;4-[(4-bromophenyl)amino]-4-keto-butyric acid
• CAS NO: 25589-41-7
• Molecular Formula: C₁₀H₁₀BrNO₃
• Molecular Weight: 272.11
• Mol File: 25589-41-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 187.2-188.2 °C
• Boiling Point: 501.1°C at 760 mmHg
• Flash Point: 256.8°C
• Appearance: /
• Density: 1.635g/cm³
• Vapor Pressure: 7.35E-11mmHg at 25°C
• Refractive Index: 1.628
• PKA: 4.60±0.10(Predicted)
• CAS DataBase Reference: 4-[(4-bromophenyl)amino]-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-bromophenyl)amino]-4-oxobutanoic acid(25589-41-7)
• EPA Substance Registry System: 4-[(4-bromophenyl)amino]-4-oxobutanoic acid(25589-41-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 25589-41-7(Hazardous Substances Data)

Usage

General Description

"4-[(4-bromophenyl)amino]-4-oxobutanoic acid" is a chemical compound with the molecular formula C10H10BrNO3. It is a derivative of butanoic acid containing a 4-oxo group and a 4-bromophenylamino group. 4-[(4-bromophenyl)amino]-4-oxobutanoic acid is commonly used in the synthesis of pharmaceuticals and organic compounds. It has potential applications in the medical field due to its structural properties and reactivity. Additionally, it may have uses in the production of specialty chemicals and materials due to its unique molecular structure.

InChI:InChI=1/C10H10BrNO3/c11-7-1-3-8(4-2-7)12-9(13)5-6-10(14)15/h1-4H,5-6H2,(H,12,13)(H,14,15)

Upstream product

• 108-30-5 succinic acid anhydride 
• 106-40-1 4-bromo-aniline 
• 102-14-7 N-phenyl-succinamic acid 

Downstream Products

• 41167-74-2 1-(4-bromophenyl)pyrrolidine-2,5-dione 
• 1266620-10-3 C₁₉H₂₈BrN₃O₂ 
• 1225562-86-6 C₁₀H₁₂BrNO₂ 
• 356550-51-1 C₁₂H₁₄BrNO₃ 

Relevant articles and documents

N-Aryl Amides as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agents

Chemical exchange saturation transfer (CEST) MRI has recently emerged as a versatile molecular imaging approach in which diamagnetic compounds can be utilized to generate an MRI signal. To expand the scope of CEST MRI applications, herein, we systematical

Radical-mediated dehydrative preparation of cyclic imides using (NH4)2S2O8-DMSO: Application to the synthesis of vernakalant

Ammonium persulfate-dimethyl sulfoxide (APS-DMSO) has been developed as an efficient and new dehydrating reagent for a convenient one-pot process for the synthesis of miscellaneous cyclic imides in high yields starting from readily available primary amines and cyclic anhydrides. A plausible radical mechanism involving DMSO has been proposed. The application of this facile one-pot imide forming process has been demonstrated for a practical synthesis of vernakalant.

A facile and green synthesis of N-substituted imides

Anhydrides 1, 6 and 10 have been reacted, independently, with aromatic primary amines 2 in solid phase by simple physical grinding of reactants with p-toluenesulphonicacid as a catalyst to yield corresponding open chain derivatives, monoacid monoamides3,7 and 11 respectively. The latter have each been transformed into the corresponding cyclic derivatives, i.e. imides 5, 9 and 13 respectively in solid phase by simple physical grinding of each with K 2CO3, alkylating agent and tetrabutylammoniumbromide as a catalyst with short reaction times. These cyclic imides can also be obtained by physical grinding of each of 3, 7 and 11 with dicyclohexylcarbodimide as a dehydrating agent in solid phase.