25613-60-9 Usage
Uses
Used in Pharmaceutical Industry:
Z-L-Phenylalanine N-carboxyanhydride is used as a building block for the synthesis of polypeptides and proteins, which are crucial in the development of new drugs and therapeutic agents. Its ability to form peptide bonds allows for the creation of complex protein structures that can be tailored for specific medical applications.
Used in Biochemical Research:
In the field of biochemistry, Z-L-Phenylalanine N-carboxyanhydride is employed as a key component in the study of protein synthesis and structure. Its role in peptide bond formation is essential for understanding the fundamental processes of protein assembly and function.
Used in Laboratory Experiments:
Z-L-Phenylalanine N-carboxyanhydride is used as a reagent in various laboratory experiments, particularly those focused on protein synthesis and polymer chemistry. Its rapid polymerization properties make it an ideal candidate for the development of new techniques and methodologies in these areas.
Used in Polymer Chemistry:
In the realm of polymer chemistry, Z-L-Phenylalanine N-carboxyanhydride is utilized as a monomer in the synthesis of novel polymers with potential applications in various industries, such as materials science, electronics, and biotechnology. Its unique properties contribute to the development of innovative materials with tailored characteristics.
Check Digit Verification of cas no
The CAS Registry Mumber 25613-60-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,6,1 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 25613-60:
(7*2)+(6*5)+(5*6)+(4*1)+(3*3)+(2*6)+(1*0)=99
99 % 10 = 9
So 25613-60-9 is a valid CAS Registry Number.
25613-60-9Relevant academic research and scientific papers
Practical syntheses of chiral α-amino acids and chiral half-esters by kinetic resolution of urethane-protected α-amino acid N-carboxyanhydrides and desymmetrization of cyclic meso-anhydrides with new modified cinchona alkaloid catalysts
Ishii, Yutaka,Fujimoto, Ryosuke,Mikami, Masafumi,Murakami, Satoshi,Miki, Yasushi,Furukawa, Yoshiro
, p. 609 - 615 (2012/12/31)
The large-scale applications of the kinetic resolution of urethane-protected α-amino acid N-carboxyanhydrides (UNCAs) and the desymmetrization of cyclic meso-anhydrides using modified cinchona alkaloids are described. These asymmetric reactions are effective organocatalytic methods for the synthesis of chiral a-amino acids 6 and chiral half-esters 2 on an industrial scale, because the organocatalyst recovery and product purification can be carried out by a simple extractive procedure obviating a chromatographic purification step. The modified cinchona alkaloid catalysts (DHQD) 2AQN and (DHQ)2AQN, as reported by Deng and co-workers, are not readily available and therefore not suitable for industrial-scale synthesis. Various O-alkylated quinidine and quinine derivatives were prepared and screened as catalysts for the kinetic resolution of phenylalanine UNCA with alcohol. The readily prepared O-propargylquinidine (OPQD) and O-propargylquinine (OPQ) were discovered to be highly enantioselective and practical catalysts. These new catalysts were applied to the synthesis of chiral propargylglycine 24 and the key intermediate of BAY10-8888/PLD-118, 26, on an industrial scale, by the kinetic resolution of UNCA 22 and the desymmetrization of cyclic meso-anhydride 25, respectively.
