256224-13-2Relevant articles and documents
An improved process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine
McPherson, Andrew K.,Capaldi, Daniel,Chen, Lijian,Olsen, Philip
, p. 2583 - 2590 (2020/12/29)
A revised, optimized process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2- methoxyethyl)guanosine (MOE G PNS) that controls critical impurities to less than 0.2% was developed. The 2′-O-alkylation of 2,6-diaminopurine riboside
2'-O-MOE-3'-H-phosphorothioate nucleoside monomer and synthetic method thereof
-
Paragraph 0051; 0052, (2017/01/23)
The invention discloses 2'-O-MOE-3'-H-phosphorodithioate ribonucleotide and 2'-O-MOE-3'-H-phosphorothioate ribonucleotide and precursor compounds thereof, preparation methods and applications of the 2'-O-MOE-3'-H-phosphorodithioate ribonucleotide and the
Synthesis study of 2′-O-(2-methoxyethyl)-purine derivatives
Sivets, Grigorii G.
, p. 1237 - 1240 (2008/09/18)
Alkylation of adenosine and 2-aminoadenosine was studied in dimethylsulfoxide with application of 1-methanesulfonyloxy-2-methoxyethane as an alkylating agent and t-BuOK, KOH and NaH as bases under mild heating. Using new reaction conditions, the improved synthesis of 2′-O-MOE-purine derivatives is described. Copyright Taylor & Francis Group, LLC.