Journal of Medicinal Chemistry p. 369 - 381 (2020)
Update date:2022-08-02
Topics:
Hlavá?, Matú?
Ková?iková, Lucia
Prnová, Marta ?oltésová
?ramel, Peter
Addová, Gabriela
Májeková, Magdaléna
Hanquet, Gilles
Bohá?, Andrej
?tefek, Milan
Inhibition of aldose reductase (AR), the first enzyme of the polyol pathway, is a promising approach in treatment of diabetic complications. We proceeded with optimization of the thioxotriazinoindole scaffold of the novel AR inhibitor cemtirestat by repla
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