25627-81-0Relevant articles and documents
Novel approach to the synthesis of 3-acyl substituted indolizines. The synthesis of 3-(indolizinyl-2)alanine and 4-(indolizinyl-3) homoalanine derivatives
Jukic, Lucija,Bratusek, Urska,Skof, Marko,Svete, Jurij,Stanovnik, Branko
, p. 1295 - 1299 (1996)
A novel approach to the synthesis of 3-acylindolizines and the transformations of some hetarylacetic acids into tryptophane analogues are described. Reaction of ethyl 2-pyridinylacetate and methyl 2-quinolinylacetate with N-trifluoroacetyl-5-bromo-4-oxonorvaline methyl ester led to N-trifluoroacetyl-3-(1-ethoxycarbonylindolizinyl-2) alanine methyl ester and N-trifluoroacetyl-3-(3-methoxycarbonylpyrrolo [1,2-a]quinolinyl-2) alanine methyl ester, respectively. Treatment of ethyl 2-pyridinylacetate and 2-pyridinylacetonitrile, first with N,N-dimethylformamide dimethyl acetal (DMFDMA), followed by reaction with phenacyl bromide, gave the corresponding 3-benzoylindolizines, while the reaction of ethyl 2-pyridinylacetate and 2-pyridinylacetonitrile with DMFDMA, followed by treatment with (S)-N-trifluoroacetyl-5-bromo-4-oxonorvaline methyl ester, gave the corresponding N-trifluoroacetyl-4-oxo-4-(indolizinyl-3)homoalanine methyl esters. 1997 Plenum Publishing Corporation.
Iodine-mediated one-pot synthesis of C-3 acylated indolizines from pyridines, aryl methyl ketones and acrylate derivatives
Fang, Youlai,He, Lisheng,Pan, Weidong,Yang, Yuzhu
supporting information, p. 3767 - 3771 (2019/06/08)
An I2/CuI-promoted multi-component reaction from pyridines, aryl methyl ketones and electron deficient acrylates has been accomplished in a “one-pot” manner, which provides a straightforward and efficient access to C-3 acylated indolizines. The
Preparation method of C-3 arylformylindolizine compounds
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Paragraph 0030-0033; 0036; 0039; 0051-0055, (2019/09/16)
The invention discloses a preparation method of C-3 arylformylindolizine compounds. The method comprises the following steps: adding a metal additive, elemental iodine, a pyridine derivative, aromaticethanone, an electron deficient olefin and a base into
Visible-Light-Induced Carbo-2-pyridylation of Electron-Deficient Alkenes with Pyridinium Salts
Hu, Rong-Bin,Sun, Shuai,Su, Yijin
supporting information, p. 10877 - 10880 (2017/08/30)
A simple and practical visible-light-induced carbo-2-pyridylation of electron-deficient alkenes with readily available N-benzoylmethylpyridinium bromides is reported. More than 40 examples are presented and proceed in greater than 80 % yield (on average)
Transition-Metal-Free Synthesis of Indolizines from Electron-Deficient Alkenes via One-Pot Reaction Using TEMPO as an Oxidant
Shi, Fei,Zhang, Yu,Lu, Zhaole,Zhu, Xiaolei,Kan, Weiqiu,Wang, Xiang,Hu, Huayou
, p. 413 - 420 (2016/01/28)
A one-pot method for the synthesis of multisubstituted indolizines from α-halo carbonyl compounds, pyridines, and electron-deficient alkenes is reported. The oxidative dehydrogenation reaction takes place under transition-metal-free conditions using TEMPO as an oxidant. This protocol uses ready available starting materials in a convenient procedure under mild reaction conditions.
One-pot synthesis of indolizine via 1,3-dipolar cycloaddition using a sub-equivalent amount of K2Cr2O7 as an efficient oxidant under base free conditions
Wang, Chao,Hu, Huayou,Xu, Juanfang,Kan, Weiqiu
, p. 41255 - 41258 (2015/05/20)
A one-pot method for synthesizing multi-substituted indolizines from α-halo-carbonyl compounds, pyridines and electron deficient alkenes was developed. A sub-equivalent amount of potassium dichromate was used as an oxidant under base free conditions. The transformation developed should be of economic efficiency.
A direct method for the synthesis of indolizine derivatives from easily available aromatic ketones, pyridines, and acrylonitrile derivatives
Cai, Qun,Zhu, Yan-Ping,Gao, Yang,Sun, Jing-Jing,Wu, An-Xin
supporting information, p. 414 - 419 (2013/07/25)
A concise and efficient strategy has been proposed to synthesize indolizine derivatives from easily available aryl or heteroaryl methyl ketones, pyridines, and acrylonitriles. The mechanistic pathway involved the integration of iodination, pyridinium ylid
Palladium-catalyzed oxidative C-H bond and C=C double bond cleavage: C-3 acylation of indolizines with α,β-unsaturated carboxylic acids
Yang, Yuzhu,Chen, Li,Zhang, Zhaoguo,Zhang, Yuhong
supporting information; experimental part, p. 1342 - 1345 (2011/05/08)
A novel palladium-catalyzed C-3 acylation of indolizines with α,β-unsaturated carboxylic acids via C-H bond and C=C double bond cleavage under oxidative conditions is described. The regioselectivity is assisted by the carboxylic group, and the selection of the oxidant is crucial to the reaction.
Substituted 1-benzoyl-3-cyano-pyrrolo [1,2-a] quinolines and analogs as activators of caspases and inducers of apoptosis
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Page/Page column 16, (2008/06/13)
The present invention is directed to substituted 1-benzoyl-3-cyano-pyrrolo[1,2-a]quinolines and analogs thereof, represented by the general Formula I: wherein R1—R8, L, Q, dash line and Ar are defined herein. The present invention al
A Facile Obe-step Synthesis of Aromatic Indolizines by 1,3-Dipolar Cycloaddition of Pyridinium and Related Heteroaromatic Ylides with Akenes in the Presence of TPCD
Wei, Xudong,Hu, Yuefei,Li, Tingsheng,Hu, Hongwen
, p. 2487 - 2490 (2007/10/02)
A facile and general one-step method is presented for the synthesis of aromatic indolizine compounds 3a-n in moderate to high yields (53-99percent) by reaction of the pyridinium N-ylides 1a-e, the quinolinium N-ylide 11f and the isoquinolinium N-ylide 1g
