493038-85-0

Basic information

• Product Name: 3-(DIMETHYLAMINO)-2-(2-PYRIDINYL)ACRYLONITRILE
• Synonyms: 3-(DIMETHYLAMINO)-2-(2-PYRIDINYL)ACRYLONITRILE;(2Z)-3-(dimethylamino)-2-pyridin-2-ylacrylonitrile;(Z)-3-dimethylamino-2-(2-pyridyl)acrylonitrile;(Z)-3-dimethylamino-2-(2-pyridyl)prop-2-enenitrile;(Z)-3-dimethylamino-2-pyridin-2-yl-prop-2-enenitrile;(Z)-3-dimethylamino-2-pyridin-2-ylprop-2-enenitrile;3-dimethylamino-2-(2-pyridyl)acrylonitrile;3-dimethylamino-2-(2-pyridyl)prop-2-enenitrile
• CAS NO: 493038-85-0
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173.21
• Mol File: 493038-85-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 70-72
• Appearance: /
• CAS DataBase Reference: 3-(DIMETHYLAMINO)-2-(2-PYRIDINYL)ACRYLONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(DIMETHYLAMINO)-2-(2-PYRIDINYL)ACRYLONITRILE(493038-85-0)
• EPA Substance Registry System: 3-(DIMETHYLAMINO)-2-(2-PYRIDINYL)ACRYLONITRILE(493038-85-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 493038-85-0(Hazardous Substances Data)

Upstream product

• 2739-97-1 pyridine-2-acetonitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 493038-87-2 5-amino-4-(pyridin-2-yl)-1H-pyrazole 
• 25627-81-0 3-benzoylindolizine-1-carbonitrile 

Relevant articles and documents

Microwave-assisted protocols for the expedited synthesis of pyrazolo[1,5-a] and [3,4-d]pyrimidines

General, high-yielding MAOS protocols for the expedited synthesis of functionalized pyrazolo[1,5-a]pyrimidines and pyrazolo[3,4-b]pyrimidines, as well as their pyrazole precursors, are described amenable to an iterative analogue library synthesis strategy for lead optimization.

Novel approach to the synthesis of 3-acyl substituted indolizines. The synthesis of 3-(indolizinyl-2)alanine and 4-(indolizinyl-3) homoalanine derivatives

A novel approach to the synthesis of 3-acylindolizines and the transformations of some hetarylacetic acids into tryptophane analogues are described. Reaction of ethyl 2-pyridinylacetate and methyl 2-quinolinylacetate with N-trifluoroacetyl-5-bromo-4-oxonorvaline methyl ester led to N-trifluoroacetyl-3-(1-ethoxycarbonylindolizinyl-2) alanine methyl ester and N-trifluoroacetyl-3-(3-methoxycarbonylpyrrolo [1,2-a]quinolinyl-2) alanine methyl ester, respectively. Treatment of ethyl 2-pyridinylacetate and 2-pyridinylacetonitrile, first with N,N-dimethylformamide dimethyl acetal (DMFDMA), followed by reaction with phenacyl bromide, gave the corresponding 3-benzoylindolizines, while the reaction of ethyl 2-pyridinylacetate and 2-pyridinylacetonitrile with DMFDMA, followed by treatment with (S)-N-trifluoroacetyl-5-bromo-4-oxonorvaline methyl ester, gave the corresponding N-trifluoroacetyl-4-oxo-4-(indolizinyl-3)homoalanine methyl esters. 1997 Plenum Publishing Corporation.