25634-96-2

Basic information

• Product Name: Benzenepropanoic acid, a-cyano-b-phenyl-, ethyl ester
• CAS NO: 25634-96-2
• Molecular Formula: C18H17NO2
• Molecular Weight: 279.338
• Mol File: 25634-96-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-cyano-b-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-cyano-b-phenyl-, ethyl ester(25634-96-2)
• EPA Substance Registry System: Benzenepropanoic acid, a-cyano-b-phenyl-, ethyl ester(25634-96-2)

Safety Data

• Hazardous Substances Data: 25634-96-2(Hazardous Substances Data)

Upstream product

• 5232-99-5 etocrylene 
• 60-29-7 diethyl ether 
• 42466-67-1 ethyl (ethoxymethylene)cyanoacetate 
• 591-51-5 phenyllithium 
• 2169-69-9 ethyl (E)-2-cyano-3-phenyl-2-propenoate 
• 2025-40-3 ethyl benzylidenecyanoacetate 
• 98-80-6 phenylboronic acid 
• 91-01-0 1,1-Diphenylmethanol 
• 100-58-3 phenylmagnesium bromide 
• 100-52-7 benzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 613-31-0 9,10-dihydroanthracene 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 530-48-3 1,1-Diphenylethylene 

Downstream Products

• 20168-13-2 (2-RS)-2-cyano-3,3-diphenylpropanoic acid 
• 86345-21-3 α-cyano-3,3-diphenylpropionic acid hydrazide 
• 119769-10-7 α-cyano-3,3-diphenylpropionic acid 2-(aminocarbonyl) hydrazide 
• 119768-95-5 5-amino-4-diphenylmethyl-3-hydroxy-1H-pyrazole-1-carboxamide 

Relevant articles and documents

Reduction of Electron-Deficient Alkenes Enabled by a Photoinduced Hydrogen Atom Transfer

Direct hydrogen atom transfer from a photoredox-generated Hantzsch ester radical cation to electron-deficient alkenes has enabled the development of an efficient formal hydrogenation under mild, operationally simple conditions. The HAT-driven mechanism is supported by experimental and computational studies. The reaction is applied to a variety of cinnamate derivatives and related structures, irrespective of the presence of electron-donating or electron-withdrawing substituents in the aromatic ring and with good functional group compatibility. (Figure presented.).

Rh-catalyzed 1,4-addition reactions of arylboronic acids accelerated by co-immobilized tertiary amine in silica mesopores

Mesoporous silica-supported Rh complex catalysts were prepared by simple silane-coupling, followed by complexation, and characterized by FT-IR, SEM, Rh K-edge XAFS, and elemental analysis. Local structures of the Rh complexes in each sample were almost similar to those of a nonporous silica-supported diaminorhodium complex. Co-immobilization of a tertiary amine on the same silica surface induced slight changes to the Rh complex structure in the case of the support with smaller pores. The prepared catalysts showed high activity for the 1,4-addition reaction of phenylboronic acids. Co-immobilization of the tertiary amine increased the reaction rate by more than 7-fold, with turnover number of nearly 8500. The catalytic performance achieved with this novel system is with much higher than that reported previously with a nonporous silica-supported catalyst. The mesoporous silica-supported Rh complex-tertiary amine showed a wide substrate scope, including unsaturated ketones and nitriles. This co-immobilized tertiary amine may activate phenylboronic acid to enhance its reactivity in the transmetalation step with Rh-OH species.

Conjugate reduction of α,β-unsaturated carbonyl and carboxyl compounds with poly(methylhydrosiloxane) catalyzed by a silica-supported compact phosphane-copper complex

A silica-supported, cage-type, compact phosphane (Silica-SMAP) was used for the copper-catalyzed conjugate reduction of α,β-unsaturated carbonyl and carboxyl compounds with poly(methylhydrosiloxane) (PMHS). The heterogeneous catalyst system showed high activity and chemoselectivity, and was easily separable from the reaction mixture after the reaction. Furthermore, the catalyst was reusable without loss of its high catalytic activity or selectivity.