18615-86-6 Usage
Uses
Used in Pharmaceutical Industry:
4-Hydroxy-2-methylpyridine is used as a key intermediate in the synthesis of novel indolizine compounds, which serve as inhibitors of phosphodiesterase IV (PDE4). PDE4 inhibitors have been found to have potential therapeutic applications in treating various inflammatory and autoimmune diseases, such as chronic obstructive pulmonary disease (COPD), asthma, and rheumatoid arthritis. The compound's role in the synthesis of these inhibitors highlights its importance in the development of new drugs for these conditions.
Used in Anthelmintic Applications:
In the field of antiparasitic drug development, 4-Hydroxy-2-methylpyridine is utilized in the preparation of 2-substituted imidazole ring compounds. These compounds have demonstrated potential in the treatment of human African trypanosomiasis (HAT), also known as sleeping sickness. HAT is a severe and often fatal disease caused by the parasitic protozoa Trypanosoma brucei. The development of new and effective treatments for HAT is crucial, and 4-Hydroxy-2-methylpyridine plays a significant role in this process.
Check Digit Verification of cas no
The CAS Registry Mumber 18615-86-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,1 and 5 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18615-86:
(7*1)+(6*8)+(5*6)+(4*1)+(3*5)+(2*8)+(1*6)=126
126 % 10 = 6
So 18615-86-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H7NO/c1-5-4-6(8)2-3-7-5/h2-4H,1H3,(H,7,8)
18615-86-6Relevant academic research and scientific papers
PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5
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Page/Page column 59, (2011/12/04)
The present invention provides ALK5 inhibitors of the formula (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, methods of making the compounds and intermediates thereof; and methods of using the compounds.
Enthalpies of combustion of the three hydroxy-pyridines and the four hydroxy-2-methylpyridines
Suradi, S.,Saiad, Nabila el,Pilcher, G.,Skinner, H. A.
, p. 45 - 50 (2007/10/02)
The enthalpies of combustion in oxygen at 298.15 K were measured in a static-bomb calorimeter and the enthalpies of sublimation at 298.15 K were measured by microcalorimetry for the following crystalline compounds: .The derived enthalpies of formation of the gaseous compounds are compared with theoretically predicted values for certain of these compounds.
