256372-58-4

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-((4-(TRIFLUOROMETHYL)PHENOXY)METHYL)OXIRANE is used as a key intermediate in the synthesis of organic compounds, specifically for the preparation of 2-hydroxy-3-phenoxypropylpiperazine derivatives. These derivatives are known to act as T-type calcium channel blockers, which are important in the treatment of various medical conditions related to calcium channel dysregulation.
Used in Chemical Synthesis:
In the field of chemical synthesis, (S)-2-((4-(TRIFLUOROMETHYL)PHENOXY)METHYL)OXIRANE serves as a versatile building block for the creation of a wide range of organic molecules. Its unique structure allows for various chemical reactions, such as ring-opening and functional group transformations, which can be utilized to develop new compounds with specific properties and applications.

Upstream product

• 402-45-9 4-hydroxybenzotrifluoride 
• 57044-25-4 (R)-oxiranemethanol 
• 67843-74-7 (S)-epichlorohydrin 

Downstream Products

• 851528-81-9 (R)-{4-[2-hydroxy-3-(4-trifluoromethyl-phenoxy)-propylsulfanyl]-2-methyl-phenoxy}-acetic acid ethyl ester 
• 1166991-34-9 1-((R)-3-(4-(trifluoromethyl)phenoxy)-2-hydroxypropyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol 
• 1383940-73-5 C₂₀H₂₂F₄N₂O₂ 
• 1383940-74-6 C₂₀H₂₂F₄N₂O₂ 
• 1383940-77-9 C₂₁H₂₅F₃N₂O₃ 
• 1383940-78-0 C₂₁H₂₅F₃N₂O₃ 
• 1383940-80-4 C₂₁H₂₄ClF₃N₂O₂ 
• 1383940-81-5 C₂₁H₂₄ClF₃N₂O₂ 
• 1383940-82-6 C₂₁H₂₃Cl₂F₃N₂O₂ 
• 1383940-83-7 C₂₁H₂₃ClF₄N₂O₂ 
• 1383940-85-9 C₂₁H₂₄F₄N₂O₂ 
• 851528-96-6 (R)-{4-[2-methoxymethoxy-3-(4-trifluoromethyl-phenoxy)-propylsulfanyl]-2-methyl-phenoxy}-acetic acid ethyl ester 
• 851528-79-5 (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)-sulfanyl)-2-methylphenoxy)acetic acid 
• 851528-83-1 (R)-{4-[2-ethoxy-3-(4-trifluoromethyl-phenoxy)-propylsulfanyl]-2-methyl-phenoxy}-acetic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl) piperazine derivatives as T-type calcium channel blockers

To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 2-hydroxy-3-phenoxypropyl piperazine derivatives were synthesized and evaluated for in vitro activities. Compound 6m and 6q showed high selectivity over hERG

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity

Direct anti-tuberculosis screening of commercially available compound libraries identified a novel piperidinol with interesting anti-tuberculosis activity and drug like characteristics. To generate a structure activity relationship about this hit a 22 mem

Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARδ agonists

A novel series of potent and selective PPARδ agonists, para-alkylthiophenoxyacetic acids, was identified. The synthesis and structure-activity relationships are described.

4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.