256378-55-9

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 28162-32-5 2-(2-thienyl)-1-cyanoacrylonitrile 
• 98-03-3 thiophene-2-carbaldehyde 
• 109-77-3 malononitrile 
• 22105-09-5 4‐hydroxycoumarin 
• 91-64-5 coumarin 

Relevant academic research and scientific papers

Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety

Novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety were synthesized and evaluated against acetylcholinestrase (AChE) and butylcholinestrase (BuChE). Among the synthesized compounds, N-(3-cyano-4-(4-methoxyphenyl)-5-oxo-4,5-

Rational design, synthesis and SAR study of novel warfarin analogous of 4-hydroxy coumarin-beta-aryl propanoic acid derivatives as potent anti-inflammatory agents

Synthesis of highly potent and enhanced safety profiled antiinflammatory drugs has become a challenging task in the drug discovery process. A library of warfarin analogue 3-(4?hydroxy-2-oxo-2H-chromen-3-yl)-3-arylpropanoic acid derivatives have been synthesised and their structures were established by availing different analysis techniques. The invitro COX-1/COX-2 study revealed the effective potency of the selective compounds 2b(IC50=180.45 μl/ml), 2c(IC50=21.03 μl/ml) and 2f(IC50=120.45 μl/ml) against COX-2 compared to reference drug aspirin (IC50=121.60 μl/ml). Compound 2c is more selective towards COX-2 with a high selective index of 7.42 than standard aspirin with a selective index of 4.14. Further, the target molecules were assessed for their antiinflammatory activity against MMP2 and MMP9, the results revealing a high percentage of inhibition. While, protein denaturation study displayed high potency of the compounds 2a (IC50=13.32 μg/ml), 2 g (IC50=11.14 μg/ml) and 2l (IC50=4.71 μg/ml) as compared with aspirin (IC50=13.42 μl/ml). The docking studies were established to understand the structural features responsible for biological activity and the outcome of the docking studies are indeed following the experimental results.

One-pot synthesis of 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles using sodium citrate as an organo-salt based catalyst in aqueous ethanol

Sodium citrate as a highly efficient catalyst is developed for the synthesis of functionalized 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles. This method involves a one-pot three-component reaction of aromatic aldehydes, malononitrile and 1,3

Tertiary amine-bisquaternary ammonium functionalized polyacrylonitrile fiber for catalytic synthesis of pyran-annulated heterocycles

Polyacrylonitrile fiber supported bisquaternary ammonium salts with varying interchain quaternary ammonium (QA) to tertiary amine (TA) ratio, counter ions and linker groups were prepared and characterized by TGA, FTIR, XPS, XRD, SEM, EA and water contact

Green synthesis of dihydropyrano[3,2-c]chromene derivatives using amino-terminated PAMAM dendrimer as catalyst

d-Sorbitol-cored PAMAM dendrimer (SOR-G1) was effectively synthesized by the ring opening polymerization of epichlorohydrin. The dendrimer was characterized using different spectroscopic and analytical techniques including IR and NMR spectroscopy, TG–DTA,

One-pot Synthesis of Dihydropyrano[3,2-c]chromenes and their Evaluation for Antimicrobial and in vitro Anticancer Activity

The three-component one-pot synthesis of dihydropyrano[3,2-c]chromene derivatives was obtained in good to excellent yields within short reaction time by condensing 4-hydroxycoumarin, aldehydes, and malononitrile or ethyl cyanoacetate with a catalytic amount of (diacetoxyiodo)benzene as hypervalent iodine in aqueous ethanol under reflux condition. Different aromatic aldehyde having electron donating and withdrawing groups and hetero-aromatic aldehyde were used under the same reaction condition to give the product. Newly synthesized compounds showed moderate to excellent activity when they screened for antimicrobial activity. Selected compounds were tested for anticancer activity. Compounds 4k and 4n showed good activity against human astrocytoma-glioblastoma cell line (U373MG).

Silica chemisorbed bis(hydrogensulphato)benzene (SiO2-BHSB) as a new, efficient, and recyclable catalyst for the synthesis of 5-oxopyrono[3,2-c]chromene scaffolds in water-based solvent

The synthesis of silica chemisorbed bis(hydrogensulphato)benzene (SiO2-BHSB) as a new hybrid material was achieved by a sequence of three reactions. Structural features of the synthesized SiO2-BHSB were established by using analytica

Zr@IL-Fe3O4MNPs as an efficient and green heterogeneous magnetic nanocatalyst for the one-pot three-component synthesis of highly substituted pyran derivatives under solvent-free conditions

The present study was conducted to synthesize Zr@IL-Fe3O4MNPs as a new magnetically recoverable heterogeneous catalyst, which was then characterized by Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray spectros

Ni(II)-Schiff base/SBA-15: a nanostructure and reusable catalyst for one-pot three-component green synthesis of 3,4-dihydropyrano[3,2-c]chromene derivatives

An efficient, rapid, and environmentally benign Ni(II)-Schiff base/SBA-15-catalyzed one-pot three-component cyclocondensation process was described via the reaction between malononitrile, 4-hydroxycoumarin, and various aldehydes in aqueous media for the s

One-pot cascade synthesis of benzopyrans and dihydropyrano[c]chromenes catalyzed by lipase TLIM

Lipase TLIM was reported to be an efficient, commercially available and reusable catalyst for the Knoevenagel-Michael cascade reactions of aldehydes, malononitrile/ethyl cyanoacetate and 4-hydroxycoumarin/1, 3-cyclohexanedione/dimedone in aqueous DMSO. Th