256390-71-3Relevant articles and documents
Convenient synthesis of L-proline benzyl ester
Cordova, Armando,Reed, Neal N.,Ashley, Jon A.,Janda, Kim D.
, p. 3119 - 3122 (1999)
Mesylates or tosylates of δ-hydroxy-L-norvaline esters spontaneously afford L-proline esters upon exposure to aqueous buffer in near quantitative yield. This novel reaction has led to the development of a simple route to optically active proline esters.
THIOPHOSPHATE NUCLEOSIDES FOR THE TREATMENT OF HCV
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, (2014/09/16)
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, the compounds are according to Formula 2001: where PD, Base, RA and RB are as provided herein. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors
Marsham, Peter R.,Wardleworth, J. Michael,Boyle, F. Thomas,Hennequin, Laurent F.,Kimbell, Rosemary,Brown, Melody,Jackman, Ann L.
, p. 3809 - 3820 (2007/10/03)
The synthesis is described of a series of analogues of the potent thymidylate synthase (TS) inhibitor, N-[4-[N-[(3,4-dihydr0-2,7-dimethyl-4- oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]2-fluorobenzoyl]-L-glutamic acid (4, ZM214888), in which the glutami
