256417-10-4 Usage
Description
2,6-Difluoro-4-methoxybenzaldehyde is an organic compound characterized by the presence of two fluorine atoms at the 2nd and 6th positions, a methoxy group at the 4th position, and an aldehyde functional group. It is a valuable intermediate in the synthesis of various pharmaceuticals and biologically active molecules due to its unique structural features and reactivity.
Uses
Used in Pharmaceutical Industry:
2,6-Difluoro-4-methoxybenzaldehyde is used as a building block for the synthesis of complex pharmaceutical compounds. Its unique structure and reactivity make it a valuable component in the development of new drugs with improved efficacy and selectivity.
Used in the Synthesis of G Protein-Coupled Receptor 40 Agonists:
2,6-Difluoro-4-methoxybenzaldehyde is used as a key intermediate in the preparation of potent and orally available G protein-coupled receptor 40 (GPR40) agonists. These agonists are important for the treatment of type 2 diabetes, as they help to improve insulin secretion and glucose homeostasis in patients.
Check Digit Verification of cas no
The CAS Registry Mumber 256417-10-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,6,4,1 and 7 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 256417-10:
(8*2)+(7*5)+(6*6)+(5*4)+(4*1)+(3*7)+(2*1)+(1*0)=134
134 % 10 = 4
So 256417-10-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H6F2O2/c1-12-5-2-7(9)6(4-11)8(10)3-5/h2-4H,1H3
256417-10-4Relevant articles and documents
Direct formylation of fluorine-containing aromatics with dichloromethyl alkyl ethers
Warashina, Takuya,Matsuura, Daisuke,Kimura, Yoshikazu
, p. 587 - 593 (2019/07/22)
Formylations of fluorine-containing aromatic compounds with dichloromethyl alkyl ethers have been investigated. Dichloromethyl propyl ether and dichloromethyl butyl ether have been applied for the formylation of fluorine-containing anisoles to give the corresponding aldehydes in good yields. Application of these ethers is preferable to that of methyl ether, which is prepared from volatile methyl formate. Reaction of fluorine-containing phenols with these dichloromethyl alkyl ethers did not give salicylaldehyde derivatives, leading instead to corresponding aryl formates in high yields. A plausible mechanism is discussed.
Barbier Continuous Flow Preparation and Reactions of Carbamoyllithiums for Nucleophilic Amidation
Ganiek, Maximilian A.,Becker, Matthias R.,Berionni, Guillaume,Zipse, Hendrik,Knochel, Paul
supporting information, p. 10280 - 10284 (2017/08/07)
An ambient temperature continuous flow method for nucleophilic amidation and thioamidation is described. Deprotonation of formamides by lithium diisopropylamine (LDA) affords carbamoyllithium intermediates that are quenched in situ with various electrophi
ACYCLIC IKUR INHIBITORS
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Page/Page column 90, (2010/11/26)
A compound of formula I wherein R1, R2, R3, R4 and R5 are described herein.
