256424-06-3

Upstream product

• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 10272-07-8 3.5-dimethoxyaniline 
• 122172-22-9 ethyl 2-(4-methoxyphenyl)-2-formyl acetate 
• 107-13-1 acrylonitrile 
• 190774-12-0 5,7-dimethoxy-3-(4-methoxyphenyl)-1,2-dihydro-2-quinolinone 

Downstream Products

• 256424-07-4 1-[2-(1H-1,2,3,4-tetrazol-5-yl)ethyl]-5,7-dimethoxy-3-(4-methoxyphenyl)-1,2-dihydro-2-quinolinone 

Relevant academic research and scientific papers

Pharmaceutical compositions comprising 2-quinolones

The invention concerns a pharmaceutical composition having an activity on the proliferation of clonogenic cells in tumours and comprising an efficient amount of a compound selected among the compounds of formulae (I) and (Ia) wherein: X, R1, R

3-Aryl-2-quinolone derivatives: Synthesis and characterization of in vitro and in vivo antitumor effects with emphasis on a new therapeutical target connected with cell migration

Among 25 3-aryl-2-quinolone derivatives synthesized, the antitumor activity of some of them was characterized both in vitro and in vivo. In this series, no compound appeared to be cytotoxic in vitro, as was known by the colorimetric MTT assay carried out