122172-22-9

Upstream product

• 14062-18-1 ethyl p-methoxyphenylacetate 
• 109-94-4 formic acid ethyl ester 
• 104-01-8 4-Methoxyphenylacetic acid 
• 64-17-5 ethanol 
• 802294-64-0 propionic acid 

Downstream Products

• 122172-23-0 (2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl 2-(4-methoxyphenyl)-3-oxopropanoate 
• 104309-71-9 5-(4-Methoxy-phenyl)-2-methyl-6-oxo-6H-pyran-3-carboxylic acid ethyl ester 
• 190774-12-0 5,7-dimethoxy-3-(4-methoxyphenyl)-1,2-dihydro-2-quinolinone 
• 1078133-92-2 C₂₁H₂₃NO₃ 
• 190774-08-4 5-hydroxy-7-methoxy-3-(4-methoxyphenyl)quinolin-4(1H)-one 
• 190774-10-8 5,7-dimethoxy-3-(4-methoxyphenyl)-1H-quinolin-4-one 
• 190774-07-3 (Z)-ethyl 3-((3,5-dimethoxyphenyl)amino)-2-(4-methoxyphenyl)acrylate 
• 1608153-99-6 7,8-dihydro-3-(4-methoxyphenyl)-7,7-dimethyl-6H-chromene-2,5-dione 
• 1608154-03-5 3-(4-methoxyphenyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione 
• 1608153-97-4 5-acetyl-3-(4-methoxyphenyl)-6-methyl-2H-pyran-2-one 
• 4132-52-9 4-(4-methoxyphenyl)-3H-1,2-dithiole-3-thione 
• 1375110-58-9 8-(3',4',5'-trimethoxyphenyl)imidazo[1,2-h][1,7]naphthyridin-7(10H)-one 
• 104309-73-1 5-(4-Methoxy-phenyl)-2-methyl-6-oxo-6H-pyran-3-carboxylic acid 
• 104309-67-3 3-(p-methoxyphenyl)-6-methyl-2-pyrone 

Relevant academic research and scientific papers

Synthesis and anticancer evaluation of 3-substituted quinolin-4-ones and 2,3-dihydroquinolin-4-ones

A series of 3-aryl-5,7-dimethoxyquinolin-4-ones 8 and 3-aryl-5,7-dimethoxy- 2,3-dihydroquinolin-4-ones 13 were synthesized in good yields. Demethylation under a range of conditions afforded the corresponding 5-hydroxy and 5,7-dihydroxy derivatives. Biolog

Lewis base catalyzed asymmetric hydrosilylation of α-substituted β-enamino esters: Facile access to enantioenriched β2-amino esters via dynamic kinetic resolution

A chiral Lewis base organocatalyzed asymmetric hydrosilylation of α-substituted β-enamino esters is presented. The reactions proceeded through dynamic kinetic resolution to afford various enantioenriched β2-amino esters with high yields (up to

Facile synthesis of highly substituted 2-pyrone derivatives via a tandem Knoevenagel condensation/lactonization reaction of β-formyl-esters and 1,3-cyclohexadiones

A mild and efficient tandem process for the synthesis of new highly substituted 2-pyrones starting from commercially available 2-arylacetic acids has been developed. The synthesis is based on the Knoevenagel condensation of 1,3-cyclohexadiones with various β-formyl-esters, followed by lactonization in the presence of nano ZnO (20 mol %). Moderate to high yields and readily available cheap starting materials are the key features of the present method.

Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity

We recently discovered that five- and pseudo-five-fused-ring derivatives in an imidazonaphthyridine series were promising hit compounds for the development of new DNA-intercalators. In this study, novel (dihydro)imidazo[1,6] and [1,7]naphthyridi(no)nes were prepared including pseudo-pentacycles. All the compounds synthesized were screened against four tumor cell lines. Compounds 3(b-d) showed significant in vitro cytotoxicity, and DNA intercalation properties were demonstrated at 25 μM. Imidazonaphthyridinones exhibited no DNA binding affinity despite significant growth inhibition activity. Interestingly, when a pyridinone pharmacophore was linked to the imidazo[1,2-a]pyridine scaffold, the geometric orientation of the link had a strong impact on the growth inhibition activity. From these results we conclude that the moderate cytotoxicity observed for these compounds is independent of their DNA-binding and topoisomerase inhibition activities.

Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials

A series of potential antimicrobial derivatives possessing bioisosteric replacements for the central oxazolidinone ring found in oxazolidinone antibacterials have been prepared. The design concept involved replacement of the requisite sp3-hybridized stereogenic center found at the 5-position of the oxazolidinone with a nitrogen atom. The synthesis and antibacterial activity of three such ring systems, the benzisoxazolinones, pyrroles, and isoxazolinones is described.

Venlafaxine production process

A process for the preparation of venlafaxin and/or the physiologically acceptable addition salts thereof that consists of reacting a compound of general formula (II) where R is a C1-C10alkyl, aryl, aralkyl or cycloalkyl group of 3 to 6 atoms of carbon, with a organomagnesium compound of general formula (III) where X is an atom of halogen and, if desired, a salt of the thus obtained venlafaxin is formed by reaction thereof with a physiologically acceptable acid.

Enantioselective Robinson Annulation: Synthesis of (+)-O-Methyljoubertiamine

The α-formyl ester derived from 2-(1-naphthyl)-3-borneol, as the potassium salt in moist dimethoxymethane, adds to methyl vinyl ketone to give two adducts in a ratio of 95:5.The relative configuration of the major diastereomer has been confirmed by X-ray crystallography.This diastereomer is readily carried on to (+)-O-methyljoubertiamine.The addition of such naphthylbornyl esters to Michael acceptors should constitute a general laboratory-scale procedure for the enantioselective construction of enantiomerically pure quaternary stereogenic centers.