256478-24-7

Basic information

• Product Name: N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester
• Synonyms: N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester
• CAS NO: 256478-24-7
• Molecular Weight: 510.057
• Mol File: 256478-24-7.mol

Chemical Properties

• CAS DataBase Reference: N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester(256478-24-7)
• EPA Substance Registry System: N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)glycine t-butyl ester(256478-24-7)

Safety Data

• Hazardous Substances Data: 256478-24-7(Hazardous Substances Data)

Upstream product

• 256477-32-4 N-[(1,4-Dichloro-7-isoquinolinyl)sulphonyl]-N-(cyclohexylmethyl)-glycine t-butyl ester 
• 50-01-1 guanidine hydrochloride 
• 2550-36-9 Cyclohexylmethyl bromide 
• 491-30-5 1-isoquinolone 
• 56241-09-9 4-chloro-1-(2H)-isoquinolone 
• 223671-80-5 1,4-dichloro-7-isoquinolinesulphonyl chloride 
• 256477-27-7 N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]glycine tert-butyl ester 
• 223671-81-6 4-chloro-1-oxo-1,2-dihydro-7-isoquinolinesulfonyl chloride 

Relevant articles and documents

Composition for the treatment of damaged tissue

A pharmaceutical for use in damaged tissue, such as wound, treatment (e.g. healing) is described. The pharmaceutical comprising a composition which comprises: (a) a growth factor; and (b) an inhibitor agent; and optionally (c) a pharmaceutically acceptable carrier, diluent or excipient; wherein the inhibitor agent can inhibit the action of at least one specific adverse protein (e.g. a specific protease) that is upregulated in a damaged tissue, such as a wound, environment.

Isoquinolines

Isoquinolinylguanidine compounds of formula (I): STR1 wherein the substituents are as defined herein, and salts thereof, are disclosed as urokinase inhibitors.