256488-01-4Relevant academic research and scientific papers
Synthesis of a novel Boc-protected cyclopropane-modified proline analogue
Tymtsunik, Andriy V.,Bilenko, Vitaliy A.,Ivon, Yevhen M.,Grygorenko, Oleksandr O.,Komarov, Igor V.
, p. 3847 - 3849 (2012/08/27)
The synthesis of the Boc derivative of a novel member of the cyclopropane-modified proline library, Boc-protected 5-azaspiro[2.4]heptane-6- carboxylic acid, is reported. The synthesis was performed in six steps starting from (2S,4R)-4-hydroxyproline using a modified Simmons-Smith reaction as the key step. The reaction conditions for all the steps were carefully selected to avoid racemization at the chiral centers in the intermediates and the final product.
