25650-54-8

Upstream product

• 2516-97-4 2-(methylsulfonyl)acetic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 76896-97-4 (E)-3-(4-Chloro-phenyl)-2-methanesulfonyl-acrylic acid ethyl ester 
• 20277-69-4 sodium methansulfinate 
• 66482-29-9 1-[(E)-2-bromoethenyl]-4-chlorobenzene 
• 1073-67-2 4-vinylbenzyl chloride 
• 67-68-5 dimethyl sulfoxide 
• 110-05-4 di-tert-butyl peroxide 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 23265-32-9 1-(methylsulfonyl)-2-(phenyl)diazene 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 
• 873-73-4 4-n-chlorophenylacetylene 

Downstream Products

• 37630-45-8 cis-β-(4-Chlor-styryl)-methyl-sulfon 

Relevant academic research and scientific papers

A photocatalyst-free visible-light-mediated solvent-switchable route to stilbenes/vinyl sulfones from β-nitrostyrenes and arylazo sulfones

Photocatalyst-free visible-light-mediated reactions, based on the presence of a visible-light-absorbing functional group in the starting material itself in order to exclude the often costly, hazardous, degradable and difficult to remove or recover photoredox catalysts, have been gaining momentum recently. We have employed this approach to develop a denitrative photocatalyst-free visible-light-mediated protocol for the arylation/sulfonylation of β-nitrostyrenes employing arylazo sulfones (bench-stable photolabile compounds) in a switchable solvent-controlled manner. Arylazo sulfones served as the aryl and sulfonyl radical precursors under blue LED irradiation for the synthesis oftrans-stilbenes and (E)-vinyl sulfones in CH3CN and dioxane/H2O 2?:?1, respectively. The absence of any metal, photocatalyst and additive; excellent selectivity (E-stereochemistry) and solvent-switchability; and the use of visible light and ambient temperature are the prime assets of the developed method. Moreover, we report the first photocatalyst-free visible light-driven route to synthesize stilbenes and vinyl sulfones from readily available β-nitrostyrenes.

Photocatalyst-free visible light driven synthesis of (E)-vinyl sulfones from cinnamic acids and arylazo sulfones

A photocatalyst-free visible light mediated decarboxylative sulfono functionalization protocol has been explored for the synthesis of (E)-vinyl sulfones from cinnamic acids and bench-stable arylazo sulfones. The latter have been utilized as sulfonyl radic

Direct C-H Methylsulfonylation of Alkenes with the Insertion of Sulfur Dioxide

The direct C-H methylsulfonylation of alkenes using inorganic sodium metabisulfite as the sulfur dioxide surrogate is described. This method provides convenient access to (E)-2-methyl styrenyl sulfones in good yields. In general, the in situ generated met

Eosin Y (EY) Photoredox-Catalyzed Sulfonylation of Alkenes: Scope and Mechanism

Alkyl- and aryl vinyl sulfones were obtained by eosin Y (EY)-mediated visible-light photooxidation of sulfinate salts and the reaction of the resulting S-centered radicals with alkenes. Optimized reaction conditions, the sulfinate and alkene scope, and X-ray structural analyses of several reaction products are provided. A detailed spectroscopic study explains the reaction mechanism, which proceeds through the EY radical cation as key intermediate oxidizing the sulfinate salts.

Ammonium iodide-induced sulfonylation of alkenes with DMSO and water toward the synthesis of vinyl methyl sulfones

A novel ammonium iodide-induced sulfonylation of alkenes with DMSO and water toward the synthesis of vinyl methyl sulfones is described. The process proceeded smoothly under metal-free conditions with high stereoselectivity and good functional group toler

CuSO4?·5H2O-H-phosphonate-catalyzed intermolecular C-S bond formation: Synthesis of (E)-vinyl alkylsulfones from alkynes and DMSO

A CuSO4?·5H2O-H-phosphonate-catalyzed synthesis of (E)-vinyl alkylsulfones from alkynes and widely available DMSO was developed. The present protocol provides an alternative approach to various vinyl sulfones, with the advantages of cheap catalysts, readily available starting materials, operational simplicity and high stereo- and regioselectivity.

CuI/L-proline potassium salt catalysed synthesis of vinyl sulfones via coupling reaction of vinyl bromides with sulfinic acid salts in ionic liquid

Catalysed by CuI/L-proline potassium salt, which serves as both base and ligand, the coupling reaction of vinyl bromides with sulfinic acid salts occurs at 110°C in ionic liquid to give the corresponding vinyl sulfones in good yields.