256507-84-3Relevant articles and documents
OPIOID HAPTENS, CONJUGATES, VACCINES, AND METHODS OF GENERATING ANTIBODIES
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Paragraph 0259-0260, (2020/02/14)
The disclosure provides, inter alia, opioid haptens, opioid hapten conjugates, opioid vaccines, methods of treating or preventing opioid use disorder, methods of treating opioid overdose, and methods of generating and/or isolating antibodies selective for opioids.
A convenient method for the N-acylation and esterification of hindered amino acids: Synthesis of ultra short acting opioid agonist, remifentanil
Coleman, Mark J.,Goodyear, Michael D.,Latham, David W. S.,Whitehead, Andrew J.
, p. 1923 - 1924 (2007/10/03)
A general method has been devised for the one step preparation of N- acylamino acid esters of type 7 from the corresponding a-amino acids in high yield under mild conditions and a probable mechanism is proposed.