25692-18-6

Upstream product

• 67-56-1 methanol 
• 292638-85-8 acrylic acid methyl ester 
• 100-56-1 phenylmercury(II) chloride 
• 4561-35-7 N-nitroso-N-acetyl-DL-phenylalanine 
• 13674-16-3 methyl 2-hydroxy-3-phenylpropanoate 
• 74-88-4 methyl iodide 
• 828-01-3 phenyllactic acid 
• 150-30-1 Phenylalanine 
• 34966-54-6 methyl 2-oxo-2-(o-tolyl)acetate 
• 2901-75-9 (R,S)-N-acetyl phenylalanine 

Downstream Products

• 78814-96-7 (RS)-2-methoxy-3-phenylpropanoic acid 
• 256229-07-9 2-methoxy-3-phenylpropanal 

Relevant academic research and scientific papers

Bronsted acid catalyzed formal insertion of isocyanides into a C-O bond of acetals

The Bronsted acid catalyzed formal insertion of an isocyanide into a C-O bond of an acetal is described. A diverse array of acyclic and cyclic acetals can be applied to the catalytic insertion to form α-alkoxy imidates. Functional groups, such as nitro, c

Controllable Intramolecular Unactivated C(sp3)-H Amination and Oxygenation of Carbamates

Dual catalyst-controlled intramolecular unactivated C(sp3)-H amination and oxygenation of carbamates merging visible-light photocatalysis and earth-abundant transition metal catalysis have been reported. Useful amino alcohol and diol derivatives could be selectively obtained from readily available tertiary alcohol derivatives. The possible mechanisms have been proposed via a 1,5-HAT process followed by Lewis acid-controlled cyclization. The nickel and zinc catalysts inhibit the formation of oxygenation and amination products, respectively. An interesting phenomenon of chirality transfer is also observed.

Hydrogenolysis of 1-alkoxybenzocyclobutenes with site-selective cleavage of the sterically hindered C(sp2)-C(sp3) bond

1-Alkoxybenzocyclobutenes undergo ring-opening hydrogenolysis with site-selective cleavage of the sterically hindered C(sp2)-C(sp3) bond on Pd/C.

Almond oxynitrilase-catalyzed transformation of aldehydes is strongly influenced by naphthyl and alkoxy substituents

Different α- and β-substituted aldehydes have been submitted to the catalytic action of almond oxynitrilase (PaHNL), in order to explore the influence of a stereocenter already present in the substrate on the selectivity of this enzyme. The results indicate that naphthyl and alkoxy substituents in the α- and also in the β-position to the aldehyde group significantly influence the stereochemical outcome of the PaHNL-catalyzed transformation.

Rearrangement of Carboxylates derived from N-Acetyl-N-nitroso-&α-amino-acids

While N-acetyl-N-nitrosophenylalanine thermally decomposes by the known mechanism, its carboxylate anion undergoes facile rearrangements initiated by carboxylate attack in methanol or water to give 2-methoxy- or 2-hydroxy-3-phenylpropanoic acid, respectively.