256931-40-5

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 210992-90-8 2-chloro-4,6-di(4-methoxybenzylamino)-1,3,5-triazine 

Relevant academic research and scientific papers

Novel orthogonal strategy toward solid-phase synthesis of 1,3,5-substituted triazines.

[reaction: see text] To improve upon the previous orthogonal method for synthesis of a triazine library, an alternative strategy has been developed via oxidation-activation of the thioether to the sulfone. Through a comparison between these two methods, the sulfone strategy was demonstrated as an enhanced method in the generation of highly pure triazine library compounds.

Palladium-catalyzed cross-coupling reaction of resin-bound chlorotriazines

To introduce the biaryl structure as a triazine functionality, we have developed a new synthetic route via the Suzuki cross-coupling reaction of resin-bound chlorotriazines. The Suzuki cross-coupling reaction was achieved using various arylboronic acids, Pd(PPh3)4, Cs2CO3, and dioxane. With the integration of this chemistry and our previous orthogonal methodology, the triazine library is greatly expanded to a biaryl scaffold.

Heterocyclic compounds as well as preparation method and application thereof

The invention belongs to the field of medicines and particularly relates to heterocyclic compounds with the structural characteristics shown in formula (I) or pharmaceutically acceptable salts, a preparation method and an application of the heterocyclic compounds as a nucleotide oxidative damage repairase MTH1 inhibitor. Pharmacological experiment results indicate that the compounds have significant inhabitation effects on the activity of MTH1 and can be used for preventing and treating clinical diseases related to MTH1.

The synthesis of novel 2,4,6-trisubstituted 1,3,5-triazines: A search for potential murf enzyme inhibitors

A series of new 2,4,6-trisubstituted 1,3,5-triazines, possessing a variety of substituents (-OH, -SH, -OMe, -Cl, -HNR, -SR and amino acid moieties), were synthesized and evaluated for the inhibition of the bacterial peptidoglycan biosynthesis enzyme MurF.

Solid phase synthesis of novel biaryl triazine library by suzuki cross coupling

Two methods are used to produce diaryl trisubstituted triazines. In the first method, cyanuric chloride is first reacted with a 4-alkoxybenzylamine. The product of this reaction is then reacted with a resin-bound amine, such as 4-alkoxybenzylamine, to ens

A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening

The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay. Copyrigh