256931-76-7Relevant academic research and scientific papers
Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives
Walsh,Sleevi,Sancilio
, p. 1317 - 1321 (1984)
A series of N-(2-benzoylphenyl)alanine derivatives were synthesized and tested for antiinflammatory activity in the Evans blue-carrageenan induced pleural effusion assay. The target compounds were envisioned to bind to a receptor site on the cyclooxygenase enzyme by a mechanism first proposed by Appleton and Brown. Of the 21 compounds prepared, two were found to be one-tenth as potent as indomethacin in the pleurisy model and one compound was tested and found to be weakly active in the adjuvant arthritis model.
Regiospecific functionalization of indole-2-carboxylates and diastereoselective preparation of the corresponding indolines
Collot, Valerie,Schmitt, Martine,Marwah, Padma,Bourguignon, Jean-Jacques
, p. 2823 - 2847 (2007/10/03)
The N-acyl derivatives of 3-substituted indole-2-carboxylates prepared through several routes were submitted to catalytic hydrogenation affording either cis- or trans-indoline diastereomers after quantitative C-2 epimerization.
