91409-58-4Relevant academic research and scientific papers
Heumann indole flow chemistry process
Crifar, Cynthia,Dücker, Fenja L.,Nguyen Thanh, Sacha,Kairouz, Vanessa,Lubell, William D.
, p. 10929 - 10937 (2019/08/26)
Continuous flow chemistry has improved efficiency in the Heumann indole process. 3-Substituted indoles were prepared by three flow steps performed in succession in better overall yield and shorter reaction times relative to their batch counterparts. Novel
Composition containing a penem or carbapenem antibiotic and the use of the same
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, (2008/06/13)
Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially.
Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives
Walsh,Sleevi,Sancilio
, p. 1317 - 1321 (2007/10/02)
A series of N-(2-benzoylphenyl)alanine derivatives were synthesized and tested for antiinflammatory activity in the Evans blue-carrageenan induced pleural effusion assay. The target compounds were envisioned to bind to a receptor site on the cyclooxygenase enzyme by a mechanism first proposed by Appleton and Brown. Of the 21 compounds prepared, two were found to be one-tenth as potent as indomethacin in the pleurisy model and one compound was tested and found to be weakly active in the adjuvant arthritis model.
