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Dibenzo[b,f]thiepin is a structural class of compounds explored for their neurotropic, psychotropic, and antihistamine activities. Derivatives such as 9-chloro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin have been synthesized and studied, though substitution at the 9th position was found to diminish neuroleptic activity, rendering it inactive as a central depressant or cataleptic agent. Other modifications, including alkyl and piperazino substitutions, have been investigated for their potential in treating CNS disorders, gastric conditions, and as antihistamines, highlighting the versatility of this scaffold in medicinal chemistry.

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  • 257-13-6 Structure
  • Basic information

    1. Product Name: Dibenzo[b,f]thiepin
    2. Synonyms: Dibenzo[b,f]thiepin
    3. CAS NO:257-13-6
    4. Molecular Formula: C14H10S
    5. Molecular Weight: 210.29
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 257-13-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 344°C at 760 mmHg
    3. Flash Point: 159.1°C
    4. Appearance: /
    5. Density: 1.19g/cm3
    6. Vapor Pressure: 0.000135mmHg at 25°C
    7. Refractive Index: 1.672
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: Dibenzo[b,f]thiepin(CAS DataBase Reference)
    11. NIST Chemistry Reference: Dibenzo[b,f]thiepin(257-13-6)
    12. EPA Substance Registry System: Dibenzo[b,f]thiepin(257-13-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 257-13-6(Hazardous Substances Data)

257-13-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 257-13-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,5 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 257-13:
(5*2)+(4*5)+(3*7)+(2*1)+(1*3)=56
56 % 10 = 6
So 257-13-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H10S/c1-3-7-13-11(5-1)9-10-12-6-2-4-8-14(12)15-13/h1-10H

257-13-6Relevant articles and documents

Facile synthesis of [1]benzothieno[3,2-b]benzothiophene from o-dihalostilbenes

Saito, Masahiko,Yamamoto, Tatsuya,Osaka, Itaru,Miyazaki, Eigo,Takimiya, Kazuo,Kuwabara, Hirokazu,Ikeda, Masaaki

scheme or table, p. 5277 - 5280 (2010/11/03)

A convenient one-pot synthesis of [1]benzothieno[3,2-b]benzothiophene from readily available o-dihalostilbenes using combined reagents of sodium sulfide nonahydrate (Na2S·9H2O) or sodium hydrosulfide hydrate (NaSH·nH2O) and sulfur is described along with plausible reaction paths in this intriguing reaction.

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