2570-40-3

Upstream product

• 7051-16-3 1-chloro-3,5-dimethoxybenzene 
• 124-40-3 dimethyl amine 
• 50-00-0 formaldehyd 
• 10272-07-8 3.5-dimethoxyaniline 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 77-78-1 dimethyl sulfate 

Relevant academic research and scientific papers

Additive-freeN-methylation of amines with methanol over supported iridium catalyst

An efficient and versatile zinc oxide-supported iridium (Ir/ZnO) catalyst was developed to catalyze the additive-freeN-methylation of amines with methanol. Mechanistic studies suggested that the high catalytic reactivity is rooted in the small sizes (1.4 nm) of Ir nanoparticles and the high ratio (93%) of oxidized iridium species (IrOx, Ir3+and Ir4+) on the catalyst. Moreover, the delicate cooperation between the IrOxand ZnO support also promoted its high reactivity. The selectivity of this catalyticN-methylation was controllable between dimethylation and monomethylation by carefully tuning the catalyst loading and reaction solvent. Specifically, neat methanol with high catalyst loading (2 mol% Ir) favored the formation ofN,N-dimethylated amine, while the mesitylene/methanol mixture with low catalyst loading (0.5 mol% Ir) was prone to producing mono-N-methylated amines. An environmentally benign continuous flow system with a recycled mode was also developed for the efficient production ofN-methylated amines. With optimal flow rates and amine concentrations, a variety ofN-methylamines were produced with good to excellent yields in this Ir/ZnO-based flow system, providing a starting point for the clean and efficient production ofN-methylamines with this cost-effective chemical process.

Laser welding of polymers using unsymmetrical squaraine dyes

Transmission laser welding of plastic is typically achieved by incorporating a laser absorbing dye into one of the two pieces of plastic one wishes to weld together and mediating the welding process using a laser emitting light at a suitable wavelength. Desirable properties of laser absorbing dyes include: (1) the dye is colorless in the visible region but absorbs strongly in the region at the wavelength where the laser emits, (2) the dye has a good conversion of the energy from the laser to heat, (3) the dye is stable enough to be incorporated into the molten plastic, (4) the dye is soluble in the plastic of choice to give an even distribution in the plastic, and (5) the dye is nontoxic. Here, we explore an alternative approach to achieve laser welding of colorless plastics using a laser dye that is colored, but that can be bleached after the welding process. Nonsymmetrical squaraine dyes were prepared by condensation of squaric acid and two equivalents of various 3,5-dimethoxy-N,N-dialkylanilines. After the incorporation into polyethylene and laser welding, the plastic was bleached either by heat treatment or by irradiation with a high pressure Xe-lamp giving colorless polyethylene.

Near infrared fluorescence probe for detection of Tau fibril for early diagnosis of Alzheimer's disease

The present invention provides a probe for detecting tau fiber protein, comprising a novel compound synthesized according to the present invention. The probe for detection of the present invention can effectively detect tau fiber protein, which is a major diagnostic target of Alzheimerandprime;s disease, thereby being able to be helpfully used for early diagnosis of the Alzheimerandprime;s disease.COPYRIGHT KIPO 2017

A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer's disease

In recent years, there has been growing interest in the near-infrared (NIR) fluorescence imaging of tau fibrils for the early diagnosis of Alzheimer's disease (AD). In order to develop a curcumin-based NIR fluorescent probe for tau fibrils, structural modification of the curcumin scaffold was attempted by combining the following rationales: the curcumin derivative should preserve its binding affinity to tau fibrils, and, upon binding to tau fibrils, the probe should show favorable fluorescence properties. To meet these requirements, we designed a novel curcumin scaffold with various aromatic substituents. Among the series, the curcumin derivative 1c with a (4-dimethylamino-2,6-dimethoxy)phenyl moiety showed a significant change in its fluorescence properties (22.9-fold increase in quantum yield; Kd, 0.77 μM; λem, 620 nm; Φ, 0.32) after binding to tau fibrils. In addition, fluorescence imaging of tau-green fluorescent protein-transfected SHSY-5Y cells with 1c confirmed that 1c detected tau fibrils in live cells.

Simple, efficient protocols for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine

Simple and efficient procedures for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine are described. At room temperature with a strong base, t-BuXPhos is employed as the supporting ligand; at 110 °C with a weak base, XPhos is employed as the supporting ligand. In each of these cases, commercially available solutions constitute the source of the dimethylamine, and recently disclosed precatalysts constitute the source of the ligand and Pd. This work further expands the utility of these precatalysts in reactions that benefit from an easily activated source of L1Pd(0).

Mixed Organocuprates Derived from ortho-Heterosubstituted ArCu Species. Reactions with Simple α,β-Unsaturated Ketones

We describe the reaction of new organocuprates of the form ArRTCuLi (Ar an ortho-heterosubstituted non-transferable ligand), and their reactions with simple α,β-unsaturated ketones.