2570-68-5

Usage

Uses

Used in Flavor and Fragrance Industry:
2-Methyl-6-oxo-heptanoic acid is used as a flavoring agent for its fruity, cheesy, and savory aroma, contributing to the enhancement of food and beverage products.
Used in Pharmaceutical Industry:
2-Methyl-6-oxo-heptanoic acid is used as a fragrance and flavoring agent in the pharmaceutical industry, adding pleasant scents and tastes to medications and health products.
Used in Cosmetic Industry:
In the cosmetic industry, 2-Methyl-6-oxo-heptanoic acid is utilized as a fragrance and flavoring agent to improve the sensory experience of cosmetic products.
Natural Occurrence:
2-Methyl-6-oxo-heptanoic acid can be found naturally in some fruits and dairy products, contributing to their unique flavors and aromas.
Safety Precautions:
It is important to handle 2-Methyl-6-oxo-heptanoic acid with care, as it can be irritating to the skin, eyes, and respiratory system. Proper safety measures should be taken during its production, use, and disposal to minimize potential health risks.

Upstream product

• 2816-57-1 2,6-dimethylcyclohexanone 
• 110-43-0 n-pentyl methyl ketone 
• 201230-82-2 carbon monoxide 
• 821-55-6 2-Nonanone 
• 66267-00-3 2-methyl-6-heptenoic acid 
• 55234-03-2 2-bromo-2,6-dimethyl-cyclohexanone 
• 84132-92-3 2-Methyl-2-(4-oxo-pentyl)-malonic acid 
• 1119-51-3 bromopentene 
• 97-99-4 Tetrahydrofurfuryl alcohol 
• 84132-91-2 2-Methyl-2-[3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-malonic acid diethyl ester 
• 5978-08-5 1-chloro-4-(1,3-dioxolane)-n-pentane 
• 105665-27-8 ethyl 2-acetyl-5iodo-2-methylpentanoate 
• 1036762-39-6 2-Methyl-5-(2-methyl-[1,3]dioxolan-2-yl)-pentanoic acid 
• 105665-35-8 ethyl (1RS,2RS)-1,2-dimethyl-2-hydroxycyclopentanecarboxylate 

Downstream Products

• 7047-57-6 2,6-Dimethyl-6-hydroxy-octin-7-saeure 
• 7083-09-2 (+/-)-5-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-2-methyl-pentanoic acid 
• 7047-69-0 (+/-)-5-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-2-methyl-pentanoic acid methyl ester 
• 7047-63-4 2,6-Dimethyl-octadien-5,7-saeure 
• 7047-59-8 6-hydroxy-2,6-dimethyl-oct-7-enoic acid 
• 7047-62-3 2,6,10-Trimethyl-9,11-dodecadiensaeure 
• 7047-58-7 2,6-Dimethyl-10-oxo-undecansaeure 
• 7047-60-1 2,6-Dimethyl-10-oxo-undecen-6-saeure 
• 7047-61-2 2,6,10,14-Tetramethyl-13,15-hexadiensaeure 
• 66113-31-3 (E)-3,7-dimethyl-oct-2-ene-1,8-diol 
• 84133-01-7 Toluene-4-sulfonic acid (2R,5R)-5-methyl-5-{4-[2-(3-methyl-but-2-enyl)-[1,3]dioxolan-2-yl]-pentyl}-[1,4]dioxan-2-ylmethyl ester 

Relevant academic research and scientific papers

A NOVEL SYNTHESIS OF (E)-3,7-DIMETHYL-2-OCTENE-1,8-DIOL SECRETED BY THE AFRICAN MONARCH USING THE RING-OPENING REACTION OF α-METHYL-β-PROPIOLACTONE

The regioselective ring-opening reaction of α-methyl-β-propiolactone with 3,3-ethylenedioxybutylmagnesium bromide in the presence of copper(I) catalyst afforded 2-methyl-6-oxoheptanoic acid, which was easily converted into (E)-3,7-dimethyl-2-octene-1,8-diol in good yield.

New synthesis of (±)-α-CMBHC and its confirmation as a metabolite of α-tocopherol (vitamin E)

There is currently interest in the metabolism of the various compounds which make up the vitamin E family, especially with regards to the possible use of vitamin E metabolites as markers of oxidative stress and adequate vitamin E supply. A number of vitamin E metabolites have been described to date and we have recently developed a method to extract and quantitate a range of vitamin E metabolites in human urine. During the development of this method a new metabolite of α-tocopherol was identified, which we tentatively characterised as 5-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-2-methyl-pentanoic acid (α-CMBHC). Here we describe the synthesis of α-CMBHC as a standard and confirm that it is a metabolite of α-tocopherol.

Oxidative cleavage of cycloalkanones with dioxygen catalyzed by supported catalysts or homogeneous systems: Evidence for novel active ruthenium (II) and/or (III) species

α-Substituted cycloalkanones are oxidized to oxo-acids by low-nuclearity complexes (Cu2+ or [VO2] +/[VO]2+ - exchanged Nafion beads), or homogeneous systems with ruthenium acetate complexes and [Ru(H 2O)6] (tosylate)2 in dioxygen (0.1 MPa) at 55-60 °C. The catalytic procedures compare well with previously described systems involving homogeneous catalysis with copper (II) or polyoxometalates such as "H8[PMo7V5O40] ·aq". The results complement the widely used oxidative methods for ketone cleavage in cases when protons and transition metal salts are involved. A tentative dioxygenase mechanism, involving peroxygen species, is proposed for these reactions.

Synthesis of 5- and 6-oxoalkanoic acids by copper(II) catalyzed oxidative cleavage of cycloalkanones with dioxygen

α-Substituted cycloalkanones are oxidized to oxo acids by the copper(II)/dioxygen/acetic acid/water system. This catalytic procedure compares well with the previously described systems involving vanadium precursors.

Visible Light-Driven, Copper-Catalyzed Aerobic Oxidative Cleavage of Cycloalkanones

A visible light-driven, copper-catalyzed aerobic oxidative cleavage of cycloalkanones has been presented. A variety of cycloalkanones with varying ring sizes and various α-substituents reacted well to give the distal keto acids or dicarboxylic acids with moderate to good yields.

METHOD OF PRODUCING OPTICALLY ACTIVE (S)-7-HYDROXY-6-METHYLHEPTAN-2-ONE AND PRECURSOR THEREOF

Provided is a method capable of industrially producing optically active (S)-7-hydroxy-6-methylheptan-2-one and its precursor simply and efficiently. The production method, allows a R-body preferentially hydrolyzable Aspergillus microorganism-derived esterase to act on a 2-methyl-6-oxoheptanoate (II), to produce an optically active (S)-2-methyl-6-oxoheptanoate (III).

Sesterterpenoids from the sponge Sarcotragus sp.

Nineteen new sesterterpenoids and eight known compounds were isolated from the sponge Sarcotragus sp. collected from Soheuksan Island, Korea. The structures of these compounds were determined to be linear sesterterpenoids containing furan or related oxygenated functionalities on the basis of combined chemical and spectroscopic analyses. In addition, the configurations of several previously undetermined compounds were assigned. Several compounds exhibited moderate to major antibacterial activity (compounds 1-3, 17, 18) and cytotoxicity (3, 11, 12) against the K562 cell line and inhibitory activity against isocitrate lyase (6, 13).

An easy access to 2-oxohydrazones via electrophilic α-p-tolylhydrazonylation of ketone enolates with tert-butyl p-tolylazo sulfide

The title reaction conveniently furnishes, as the sole or main products, α-(p-tolylhydrazono)ketones or their N-methylderivatives (H+ or MeI quenching of the final mixture, respectively). Although the method fails with ketones having a secondary alkyl group bonded to the carbonyl, yields are otherwise more than satisfactory and particular interest is attached to the hydrazonylation of the methyl group in methyl ketones.

The Oxidation of Ketones with a Heteropolyacid, H5 and Dioxygen

Substituted cycloalkanones, 1-phenylalkanones, and open-chain ketones are oxidatively cleaved by the title compound under very mild conditions.

A New Synthesis of (E)-3,7-Dimethyloct-2-en-1,8-diol, a Component of the Hairpencil Secretion of African Monarch Butterfly

A facile synthesis of the title compound (1) has been achieved.The key intermediate, viz, the keto acid (6) is prepared via a novel route starting from the alkenol (2).Bromination of (2), and subsequent elaboration through the alkylation of diethyl malonate or propionic acid, affords the alkenoic acid (5) which upon oxidation with Jones' reagent in presence of Hg(OAc)2, provides 6.Following a well-established sequence of reactions, 6 is then transformed into 1.