25700-10-1Relevant academic research and scientific papers
Highly selective detection of fluoride based on 2,2-diferrocenylpropane benzimidazolium borate-ester salt
Su, Zhi-Ming,Yan, Xi-Quan,Liang, Chao-Li,Lin, Cai-Xia,Xie, Li-Li,Yuan, Yao-Feng
, p. 1250 - 1255 (2016)
A new anion receptor that utilized boron-fluoride interaction and (C-H)+?F--type ionic hydrogen bonding in the binding of F ions had been synthesized and characterized by IR, MS, HRMS, 11B, 1H, and 13
Green synthesis of CuO nanoflakes from copper pincer complex for effective N-arylation of benzimidazole
Jerome,Kausalya,Daniel Thangadurai,Karvembu
, p. 50 - 54 (2015/12/24)
Nanostructured CuO is synthesized in water using copper pincer complex as precursor without any stabilizing agent and characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-
Cu(0)@Al2O3/SiO2 NPs: An efficient reusable catalyst for the cross coupling reactions of aryl chlorides with amines and anilines
Reddy, P. Linga,Arundhathi,Rawat, Diwan S.
, p. 92121 - 92127 (2015/11/17)
The C-N cross coupling reaction of aryl chlorides with various alkyl/aryl amines catalyzed by copper nanoparticles impregnated on alumina/silica support (Cu(0)@Al2O3/SiO2) was investigated. The prepared catalyst was characterized for its intrinsic physico-chemical and textural properties using XRD, XPS, HR-TEM, BET surface area, SEM-EDAX, H2-TPR and ICP-AES techniques. The catalyst exhibits excellent reactivity and efficacy in the cross-coupling of a wide range of alkyl/aryl amines including challenging anilines with aryl chlorides. The catalyst offers significant advantages such as brevity, milder reaction conditions, excellent yields and high functional group tolerance for C-N cross coupling when compared with the other reported methods. Moreover, this atom-economical methodology does not require an additional ligand or co-catalyst/activator. The Cu(0)@Al2O3/SiO2 catalyst was efficiently applied to a gram scale synthesis of 7-chloro-4-(4-(2-nitrophenyl)piperazin-1-yl)quinolone (2k). The robustness of the catalyst was examined by reusing it for five consecutive runs.
A metal-organic framework Cu2(BDC)2(DABCO) as an efficient and reusable catalyst for Ullmann-type N-arylation of imidazoles
Nguyen, Tung T.,Phan, Nam T. S.
, p. 1877 - 1883 (2015/02/19)
A highly porous metal-organic framework (Cu2(BDC)2(DABCO)) was synthesized and used as an efficient and recyclable heterogeneous catalyst for the Ullmann-type N-arylation of aryl halides with imidazoles. The Cu2(BDC)2(DABCO) was characterized by several techniques, including X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, Fourier transform infrared, atomic absorption spectrophotometry, and nitrogen physisorption measurements. The catalyst offered high activity under mild conditions, confirming outstanding advantages when employing the Cu2(BDC)2(DABCO) as catalyst for Ullmann-type N-arylation reaction. The catalyst could be separated from the reaction mixture by simple filtration, and could be reused without a significant degradation in catalytic activity.
Antimalarial Activity of Newly Synthesized Chalcone Derivatives In Vitro
Yadav, Neesha,Dixit, Sandeep K.,Bhattacharya, Amit,Mishra, Lokesh C.,Sharma, Manish,Awasthi, Satish K.,Bhasin, Virendra K.
experimental part, p. 340 - 347 (2012/08/29)
Twenty-seven novel chalcone derivatives were synthesized using Claisen-Schmidt condensation and their antimalarial activity against asexual blood stages of Plasmodium falciparum was determined. Antiplasmodial IC50 (half-maximal inhibitory concentration) activity of a compound against malaria parasites in vitro provides a good first screen for identifying the antimalarial potential of the compound. The most active compound was 1-(4-benzimidazol-1-yl-phenyl)-3-(2, 4-dimethoxy-phenyl)-propen-1-one with IC50 of 1.1μg/mL, while that of the natural phytochemical, licochalcone A is 1.43μg/mL. The presence of methoxy groups at position 2 and 4 in chalcone derivatives appeared to be favorable for antimalarial activity as compared to other methoxy-substituted chalcones. Furthermore, 3, 4, 5-trimethoxy groups on chalcone derivative probably cause steric hindrance in binding to the active site of cysteine protease enzyme, explaining the relative lower inhibitory activity.
Cu(OAc)2·H2O-catalyzed N-arylation of nitrogen-containing heterocycles
Xu, Zhong-Lin,Li, Hong-Xi,Ren, Zhi-Gang,Du, Wei-Yuan,Xu, Wei-Chang,Lang, Jian-Ping
supporting information; experimental part, p. 5282 - 5288 (2011/08/04)
In the absence of any additional ligands, the efficient N-arylation of nitrogen-containing heterocycles with aryl iodides catalyzed by relative low catalyst amount of Cu(OAc)2·H2O was developed. This simple catalytic system is involved in the C-N cross-coupling reaction and works for a variety of pyrazole, pyrrole, imidazole, triazole, indole, benzoimidazole, benzotriazole, carbazole, and anilines as well as aryl iodides with different electronic properties. Highly efficient copper(II)-catalyzed N-arylation protocol was established.
Efficacy of C-N coupling reactions with a new multinuclear copper complex catalyst and its dissociation into mononuclear species
Zou, Yan,Lin, Haisheng,Maggard, Paul A.,Deiters, Alexander
experimental part, p. 4154 - 4159 (2011/10/04)
A new tetranuclear copper(I)-pyridazine (pda)/rhenate hybrid has been synthesized under hydrothermal conditions and structurally characterized by X-ray crystallography. The activity of this catalyst, as well as its dissociation into mononuclear species, was investigated in homogeneous C-N arylation reactions. A variety of N-arylamides and-azoles were synthesized in good to excellent yields, revealing the effect of polynuclear versus mononuclear Cu complexation in this type of coupling reaction.
Use of acylhydrazine- and acylhydrazone-type ligands to promote CuI-catalyzed C-N cross-coupling reactions of aryl bromides with N-heterocycles
Li, Liuyi,Zhu, Lei,Chen, Dagui,Hu, Xuelei,Wang, Ruihu
experimental part, p. 2692 - 2696 (2011/06/25)
A series of ten acylhydrazine- and acylhydrazone-type ligands were designed and synthesized. Their electronic and steric properties were easily modified and tuned by varying the substituents in the vicinity of the acylhydrazine and acylhydrazone units. The effect of ligands on the catalytic activity of Ullmann reactions was assessed by using a combination of these ligands with CuI. The catalytic system is very efficient for the C-N coupling reaction of azoles with aryl and heteroaryl bromides. A simple and efficient procedure for copper-catalyzed C-N cross-coupling reactions between aryl bromides and NH-containingheterocycles is illustrated. Readily available acylhydrazine- and acylhydrazone-typeligands promote the reaction.
Efficient copper-catalyzed N-arylations of nitrogen-containing heterocycles and aliphatic amines in water
Li, Xufeng,Yang, Daoshan,Jiang, Yuyang,Fu, Hua
experimental part, p. 1097 - 1105 (2010/08/06)
A simple and efficient copper-catalyzed method has been developed for N-arylations of nitrogen-containing heterocycles and aliphatic amines in water. The protocol uses (1E,2E)-oxalaldehyde dioxime (OADO) as the ligand, and water as the solvent, and shows good tolerance towards various functional groups.
Cu-Al hydrotalcite: An efficient and reusable ligand-free catalyst for the coupling of aryl chlorides with aliphatic, aromatic, and N(H)-heterocyclic amines
Sreedhar,Arundhathi,Linga Reddy,Amarnath Reddy,Lakshmi Kantam
experimental part, p. 2517 - 2522 (2010/03/24)
Copper-aluminum hydrotalcite catalysts were effectively used in the coupling of aryl chlorides with aliphatic, aromatic, and N(H)-heterocyclic amines to afford the corresponding N-alkylated/arylated amines in excellent yields. The catalyst was quantitatively recovered from the reaction by simple filtration and reused for a number of cycles with almost consistent activity. Georg Thieme Verlag Stuttgart.
