2571-73-5Relevant academic research and scientific papers
Structure-activity relationships of some taxoids as multidrug resistance modulator
Hasegawa, Toshiaki,Bai, Jao,Zhang, Shujun,Wang, Jinlan,Matsubara, Junichi,Kawakami, Junichi,Tomida, Akihiro,Tsuruo, Takashi,Hirose, Katsutoshi,Sakai, Junichi,Kikuchi, Midori,Abe, Mariko,Ando, Masayoshi
, p. 1122 - 1126 (2008/01/27)
1,7-Deoxy-4-deacetylbaccatin III (12) and its five analogues 6-9, 13, and their oxetane ring opened derivatives 14, 16, and 17, which were synthesized from taxinine, showed significant activity as MDR reversal agent by the assay of the calcein accumulatio
An efficient conversion of taxinine to taxinine NN-1, an anticancer agent and a modulator of multidrug-resistant tumor cells
Zhang, Shujun,Wang, Jinlan,Hirose, Katutoshi,Ando, Masayoshi
, p. 1786 - 1792 (2007/10/03)
Taxinine NN-1 (1), which shows significant activities as a modulator of multidrug-resistant cancer cells and as an anticancer agent in an in vitro assay based on a HCC panel, was synthesized in order to obtain sufficient material for a higher order bioass
