2573-06-0

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-4-(2,2-dimethylhydrazino)-4-oxobut-2-enoic acid is utilized as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic effects. Its unique structure allows for the creation of molecules that can target specific biological pathways, offering innovative solutions to various health challenges.
Used in Agrochemical Industry:
In the agrochemical sector, (2E)-4-(2,2-dimethylhydrazino)-4-oxobut-2-enoic acid serves as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these products can enhance their effectiveness in protecting crops and managing pests, thereby contributing to increased agricultural productivity and food security.
Used in Organic Synthesis:
(2E)-4-(2,2-dimethylhydrazino)-4-oxobut-2-enoic acid is also used as a valuable building block in organic synthesis. Its reactivity and structural features make it suitable for the construction of more complex organic molecules, which can be applied across various industries, including materials science, pharmaceuticals, and agrochemicals, for the development of novel products with improved properties and functions.

Upstream product

• 108-31-6 maleic anhydride 
• 57-14-7 N,N-Dimethylhydrazine 

Downstream Products

• 10270-11-8 1-(dimethylamino)-1H-pyrrole-2,5-dione 

Relevant academic research and scientific papers

Tailoring the substitution pattern of Pyrrolidine-2,5-dione for discovery of new structural template for dual COX/LOX inhibition

Dual inhibition of the enzymatic pathways of cyclooxygenases (COX-1/COX-2) and lipoxygenase (LOX) is a rational approach for developing more efficient and safe anti-inflammatory agents. Herein, dual inhibitors of COX and LOX for the management of inflammation are reported. The structural modifications of starting pyrrolidine-2,5-dione aldehyde derivatives resulted in two structurally diverse families (Family A & B). Synthesized derivatives from both Families displayed preferential COX-2 affinity in submicromolar to nanomolar ranges. Disubstitution pattern of the most active series of compounds having N-(benzyl(4-methoxyphenyl)amino moiety presents a new template that is mimic to the diaryl pattern of traditional COX-2 inhibitors. Compound 78 with IC50 value of 0.051 ± 0.001 μM emerged as the most active compound. Highly potent COX-2/5-LOX inhibitors have also demonstrated appreciable in-vivo anti-inflammatory activity through carrageenan induced paw edema test. Moreover, the involvement of histamine, bradykinin, prostaglandin, and leukotriene mediators to adjust the inflammatory response were also studied. Apart from COX inhibition, sulfonamide is considered an important template for carbonic anhydrase inhibition. Hence, we also evaluated six sulfonamide derivatives for off-target in-vitro bovine carbonic anhydrase-II inhibition. Biological results were finally rationalized by docking simulations. Typically, most active COX-2 inhibitors interact with the amino acid residues responsible for the COX-2 selectivity.