257300-86-0

Upstream product

• 6576-31-4 desformyldistamycin A 
• 225122-40-7 4-(2-Chloroethylsulfanyl)-benzoic acid 
• 7184-99-8 4-((2-hydroxyethyl)thio)benzoic acid 
• 1074-36-8 4-mercaptobenzoic acid 

Downstream Products

• 257613-89-1 3-[1-methyl-4[1-methyl-4[1-methyl-4[4-(2-chloroethylsulfinyl)phenyl-1-carboxamido]pyrrole-2-carboxamido]pyrrole-2-carboxamido]pyrrole-2-carboxamido]propionamidine 

Relevant academic research and scientific papers

Phenyl sulfur mustard derivatives of distamycin A

The design, synthesis, and cytotoxic activity of novel benzoyl and cinnamoyl sulfur mustard derivatives of distamycin A are described and structure-activity relationships are discussed. These sulfur mustards are more potent cytotoxics than corresponding nitrogen mustards in spite of the lower alkylating power, while their sulfoxide analogues are substantially inactive. Cinnamoyl sulfur mustard derivative (7) proved to be one of the most active distamycin-derived cytotoxics, about 1000 times more potent than melphalan. (C) 2000 Elsevier Science Ltd. All rights reserved.